Reference Report

Reference
Citation	Ghazi, A., Paul, L., VijayRaghavan, K. (2003). Prepattern genes and signaling molecules regulate stripe expression to specify Drosophila flight muscle attachment sites. Mech. Dev. 120(5): 519--528. (Export to RIS)
FlyBase ID	FBrf0160549
Publication Type	Research paper
PubMed ID	12782269
PubMed Abstract	In Drosophila, muscles attach to epidermal tendon cells specified by the gene stripe (sr). Flight muscle attachment sites are prefigured on the wing imaginal disc by sr expression in discrete domains. We describe the mechanisms underlying the specification of these domains of sr expression. We show that the concerted activities of the wingless (wg), decapentaplegic (dpp) and Notch (N) signaling pathways, and the prepattern genes pannier (pnr) and u-shaped (ush) establish domains of sr expression. N is required for initiation of sr expression. pnr is a positive regulator of sr, and is inhibited by ush in this function. The Wg signal differentially influences the formation of different sr domains. These results identify the multiple regulatory elements involved in the positioning of Drosophila flight muscle attachment sites.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (1)
	Df(2L)ush^rev18
Alleles (20)
	dpp^d6 dpp^d12 Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^sr-03999 fz2^{ECD.GPI.Scer\UAS.T:Hsap\MYC} pnr^D1 pnr^MD237 pnr^Scer\UAS.cHa pnr^V1 pnr^VX1 Scer\GAL4^dpp.blk1 Scer\GAL4^pnr-MD237 Scer\GAL4^ush-MD751 sd^Scer\UAS.cVa ush¹⁵¹³ ush^rev5 ush^Scer\UAS.cCa ush^SW42 ush^VX22 wg^17en40cP1
Constructs (6)
	P{BS3.0} P{GAL4-dpp.blk1} P{UAS-fz2(ECD)-GPI} P{UAS-pnr.H} P{UAS-sd.V} P{UAS-ush.C}
Genes (11)
	ct dpp Ecol\lacZ fz2 pnr Scer\GAL4 sd sr T:Hsap\MYC ush wg
Insertions (6)
	P{en1}wg^17en40cP1 P{GawB}pnr^MD237 P{GawB}ush^MD751 P{lacZ}ush¹⁵¹³ P{lacZ}ush^rev5 P{PZ}sr⁰³⁹⁹⁹