Reference Report

Reference
Citation	Golovnin, A., Birukova, I., Romanova, O., Silicheva, M., Parshikov, A., Savitskaya, E., Pirrotta, V., Georgiev, P. (2003). An endogenous Su(Hw) insulator separates the yellow gene from the Achaete-scute gene complex in Drosophila. Development 130(14): 3249--3258. (Export to RIS)
FlyBase ID	FBrf0160557
Publication Type	Research paper
PubMed ID	12783795
PubMed Abstract	The best characterized chromatin insulator in Drosophila is the Suppressor of Hairy wing binding region contained within the gypsy retrotransposon. Although cellular functions have been suggested, no role has been found yet for the multitude of endogenous Suppressor of Hairy wing binding sites. Here we show that two Suppressor of Hairy wing binding sites in the intergenic region between the yellow gene and the Achaete-scute gene complex form a functional insulator. Genetic analysis shows that at least two proteins, Suppressor of Hairy wing and Modifier of MDG4, required for the activity of this insulator, are involved in the transcriptional regulation of Achaete-scute.
DOI
Related Publication(s)
Erratum	An endogenous Su(Hw) insulator separates the yellow gene from the Achaete-scute gene complex in Drosophila (vol 130, pg 3249, 2003). Golovnin et al., 2008, Development 135(4): 787 [FBrf0203126]
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (5)
	Df(1)ase-1 Df(3R)GC14 In(1)sc⁸ In(1)sc^V2 In(1)y^3P
Alleles (45)
	gypsy\su(Hw)BR⁴³⁰ mod(mdg4)^ul sc⁵ sc⁸ sc^+s sc^ase-1 sc^ls-1 sc^ls-2 sc^ls-3 sc^ms1 sc^ms2 sc^V2 su(Hw)² su(Hw)⁷ su(Hw)^V su(Hw)BR-y-AS-C^2kb su(Hw)BR-y-AS-C^125bp su(Hw)BR-y-AS-C^125bpx3 su(Hw)BR-y-AS-C^454bp su(Hw)BR-y-AS-C^454mut w^+mC w^{Eye2kbYSW.P1\loxP} w^{Eye2kbYSW.Scer\FRT.P1\loxP} w^{Eye2kbYSW.Scer\FRT} w^Eye2kbYSW w^{Eye125bpx3YSW.P1\loxP} w^{Eye125bpx3YSW.Scer\FRT.P1\loxP} w^{Eye125bpx3YSW.Scer\FRT} w^{Eye125bpx3YSW} w^{Eye125bpYSW.P1\loxP} w^{Eye125bpYSW.Scer\FRT.P1\loxP} w^{Eye125bpYSW.Scer\FRT} w^Eye125bpYSW w^{Eye454bpYSW.Scer\FRT.P1\loxP} w^{Eye454bpYSW.Scer\FRT} w^Eye454bpYSW y^2s y^En454mutbpYW y^{Eye2kbYSW.Scer\FRT.P1\loxP} y^{Eye2kbYSW.Scer\FRT} y^{Eye125bpx3YSW.Scer\FRT.P1\loxP} y^{Eye125bpx3YSW.Scer\FRT} y^{Eye125bpYSW.Scer\FRT.P1\loxP} y^{Eye125bpYSW.Scer\FRT} y^{Eye454bpYSW.Scer\FRT.P1\loxP}
Constructs (16)
	P{(FRT.Eye)(loxP.2kb)Eye2kbYSW} P{(FRT.Eye)(loxP.125bpx3)Eye125bpx3YSW} P{(FRT.Eye)(loxP.su(Hw)BR)Eye125bpYSW} P{(FRT.Eye)(loxP.su(Hw)BR)Eye454bpYSW} P{(FRT.Eye)(-loxP)Eye2kbYSW} P{(FRT.Eye)(-loxP)Eye125bpx3YSW} P{(FRT.Eye)(-loxP)Eye125bpYSW} P{(FRT.Eye)(-loxP)Eye454bpYSW} P{(-FRT)(loxP.2kb)Eye2kbYSW} P{(-FRT)(loxP.125bpx3)Eye125bpx3YSW} P{(-FRT)(loxP.su(Hw)BR)Eye125bpYSW} P{(-FRT)(-loxP)Eye2kbYSW} P{(-FRT)(-loxP)Eye125bpx3YSW} P{(-FRT)(-loxP)Eye125bpYSW} P{(-FRT)(-loxP)Eye454bpYSW} P{En454mutbpYW}
Genes (10)
	ac ase gypsy\su(Hw)BR l(1)sc mod(mdg4) sc su(Hw) su(Hw)BR-y-AS-C w y
Sequence features (3)
	y-protein_bind-1 y-protein_bind-2 y-reg_element-3