Reference Report

Reference
Citation	Haghighi, A.P., McCabe, B.D., Fetter, R.D., Palmer, J.E., Hom, S., Goodman, C.S. (2003). Retrograde control of synaptic transmission by postsynaptic CaMKII at the Drosophila neuromuscular junction. Neuron 39(2): 255--267. (Export to RIS)
FlyBase ID	FBrf0160587
Publication Type	Research paper
PubMed ID	12873383
PubMed Abstract	Retrograde signaling plays an important role in synaptic homeostasis, growth, and plasticity. A retrograde signal at the neuromuscular junction (NMJ) of Drosophila controls the homeostasis of neurotransmitter release. Here, we show that this retrograde signal is regulated by the postsynaptic activity of Ca2+/calmodulin-dependent protein kinase II (CaMKII). Reducing CaMKII activity in muscles enhances the signal and increases neurotransmitter release, while constitutive activation of CaMKII in muscles inhibits the signal and decreases neurotransmitter release. Postsynaptic inhibition of CaMKII increases the number of presynaptic, vesicle-associated T bars at the active zones. Consistently, we show that glutamate receptor mutants also have a higher number of T bars; this increase is suppressed by postsynaptic activation of CaMKII. Furthermore, we demonstrate that presynaptic BMP receptor wishful thinking is required for the retrograde signal to function. Our results indicate that CaMKII plays a key role in the retrograde control of homeostasis of synaptic transmission at the NMJ of Drosophila.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (1)
	Df(2L)cl-h4
Alleles (13)
	CaMKII^{T287D.Scer\UAS} GluRIIA^{M614R.Scer\UAS.T:Hsap\MYC} GluRIIA^SP16 Rat\CamKII-I^Ala.Scer\UAS Rat\CaMKIINα^{I.Scer\UAS.cHa} Scer\GAL4^C142 Scer\GAL4^elav.PLu Scer\GAL4^G14 Scer\GAL4^Mef2.PR Scer\GAL4^Mhc.PW wit^HA4 wit^HA5 wit^unspecified
Constructs (7)
	P{GAL4-elav.L} P{GAL4-Mef2.R} P{GAL4-Mhc.W} P{UAS-CaMKII.T287D} P{UAS-CamKII-I.Ala} P{UAS-CaMKIINα.I} P{UAS-GluRIIA.M614R}
Genes (8)
	CaMKII GluRIIA Rat\CamKII-I Rat\CaMKIINα Scer\GAL4 Syt1 T:Hsap\MYC wit
Insertions (2)
	P{GAL4}C142 P{GAL4}G14
Transcripts (2)
	Scer\GAL4^C142RA Scer\GAL4^Mef2.PRRA