Reference Report

Reference
Citation	Jang, C.C., Chao, J.L., Jones, N., Yao, L.C., Bessarab, D.A., Kuo, Y.M., Jun, S., Desplan, C., Beckendorf, S.K., Sun, Y.H. (2003). Two Pax genes, eye gone and eyeless, act cooperatively in promoting Drosophila eye development. Development 130(13): 2939--2951. (Export to RIS)
FlyBase ID	FBrf0160635
Publication Type	Research paper
PubMed ID	12756177
PubMed Abstract	We report the identification of a Drosophila Pax gene, eye gone (eyg), which is required for eye development. Loss-of-function eyg mutations cause reduction or absence of the eye. Similar to the Pax6 eyeless (ey) gene, ectopic expression of eyg induces extra eye formation, but at sites different from those induced by ey. Several lines of evidence suggest that eyg and ey act cooperatively: (1) eyg expression is not regulated by ey, nor does it regulate ey expression, (2) eyg-induced ectopic morphogenetic furrow formation does not require ey, nor does ey-induced ectopic eye production require eyg, (3) eyg and ey can partially substitute for the function of the other, and (4) coexpression of eyg and ey has a synergistic enhancement of ectopic eye formation. Our results also show that eyg has two major functions: to promote cell proliferation in the eye disc and to promote eye development through suppression of wg transcription.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (2)
	Df(3L)C1 In(3L)gv^U
Alleles (16)
	BacA\p35^Scer\UAS.cHa Ecol\lacZ^dpp.BS3.0 ey² ey^D ey^Scer\UAS.cHa eyg¹ eyg^22-2 eyg^37-1 eyg^94-4 eyg^Eq-2-d2-2 eyg^hs.lune eyg^M3-12 eyg^{Scer\UAS.lune} Scer\GAL4^dpp.blk1 Scer\GAL4^ey.PH Scer\GAL4^upd-E132
Constructs (7)
	P{BS3.0} P{GAL4-dpp.blk1} P{GAL4-ey.H} P{hs-eyg.lune} P{UAS-ey.H} P{UAS-eyg.lune} P{UAS-p35.H}
Genes (7)
	BacA\p35 Ecol\lacZ ey eyg futsch Scer\GAL4 toe
Insertions (12)
	Doc{}ey² P{BS3.0}H1-1 P{GAL4-dpp.blk1}40C.6 P{GAL4-dpp.blk1}c40.1 P{GAL4-dpp.blk1}c40.6 P{GawB}E132 P{GawB}EM458 P{GawB}eyg^22-2 P{GawB}eyg^37-1 P{GawB}eyg^94-4 P{lacW}Eq-1 P{lacW}Eq-2