Reference Report

Reference
Citation	Li, T.R., White, K.P. (2003). Tissue-specific gene expression and ecdysone-regulated genomic networks in Drosophila. Dev. Cell 5(1): 59--72. (Export to RIS)
FlyBase ID	FBrf0160735
Publication Type	Research paper
PubMed ID	12852852
PubMed Abstract	During insect metamorphosis, each tissue displays a unique physiological and morphological response to the steroid hormone 20-hydroxyecdysone (ecdysone). We assayed gene expression in five tissues during metamorphosis onset. Larval-specific tissues display major changes in genome-wide expression profiles, whereas tissues that survive into adulthood display few changes. In one larval tissue, the salivary gland, we used a computational approach to identify a regulatory motif and a cognate transcription factor involved in regulating a set of coexpressed genes. During the metamorphosis of another tissue, the midgut, genes encoding factors from the hedgehog, Notch, EGF, dpp, and wingless pathways are activated by the ecdysone regulatory network. Mutation of the ecdysone receptor abolishes their induction. Cell cycle genes are also activated during the initiation of midgut metamorphosis, and they are also dependent on ecdysone signaling. These results establish multiple new connections between the ecdysone regulatory network and other well-studied regulatory networks.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Alleles (5)
	EcR^B2.hs EcR^M554fs EcR^V559fs sage^{dsRNA.Scer\UAS} Scer\GAL4^hs.PB
Constructs (3)
	P{GAL4-Hsp70.PB} P{hs-EcR.B2} P{UAS-sage.dsRNA}
Genes (101)
	Ark arm ase br cdc2 cdc2c Cdc16 CG7587 CG7606 CG9040 CG10782 CG10918 CG11300 CG12310 CG12360 CG12715 CG13460 CG13461 CG13560 CG13947 CG14265 CG17362 ci crp CycB CycC CycD CycE CycJ da Dad dap Dat Ddc decay Dl DNApol-δ dsh e E(spl)mα-BFM E(spl)mβ-HLH EcR Egfr Eig71Ee Eip74EF Eip75B Eip93F ftz-f1 fzy gbb gcm Hex-A hh Hr39 Hr46 Hr78 Hr96 Hus1-like Ilp2 Krn kuz l(1)G0148 l(3)93Dl Mcm2 Mcm5 mus209 Nc ncd ng1 ng2 ng3 Orc2 pav Pfk Pig1 ple Pvf1 Pvr PyK Rad23 rap rho rpr sage Scer\GAL4 sgg Sgs1 Sgs3 Sgs4 Sgs5 Sgs6 Sgs7 Sgs8 skpA smo sra Su(H) sub vg vn wg