Reference Report

Reference
Citation	Lundell, M.J., Lee, H.K., Perez, E., Chadwell, L. (2003). The regulation of apoptosis by Numb/Notch signaling in the serotonin lineage of Drosophila. Development 130(17): 4109--4121. (Export to RIS)
FlyBase ID	FBrf0160755
Publication Type	Research paper
PubMed ID	12874131
PubMed Abstract	Apoptosis is prevalent during development of the central nervous system (CNS), yet very little is known about the signals that specify an apoptotic cell fate. In this paper, we examine the role of Numb/Notch signaling in the development of the serotonin lineage of Drosophila and show that it is necessary for regulating apoptosis. Our results indicate that when Numb inhibits Notch signaling, cells undergo neuronal differentiation, whereas cells that maintain Notch signaling initiate apoptosis. The apoptosis inhibitor p35 can counteract Notch-mediated apoptosis and rescue cells within the serotonin lineage that normally undergo apoptosis. Furthermore, we observe tumor-like overproliferation of cells in the CNS when Notch signaling is reduced. These data suggest that the distribution of Numb during terminal mitotic divisions of the CNS can distinguish between a neuronal cell fate and programmed cell death.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(3L)H99
Alleles (7)
	BacA\p35^Scer\UAS.cHa Dl::N^{ΔECN.Scer\UAS} Ecol\lacZ^eg-P289 numb¹ numb^Scer\UAS.cWa Scer\GAL4^eg-Mz360 spdo^G104
Constructs (3)
	P{UAS-Dl::N.ΔECN} P{UAS-numb.W} P{UAS-p35.H}
Genes (13)
	BacA\p35 Crz Ddc Dl::N Ecol\lacZ eg hb nub numb Scer\GAL4 spdo zfh1 zfh2
Insertions (2)
	P{GawB}eg^Mz360 P{lArB}eg^P289
Transcripts (1)
	Ecol\lacZ^eg-P289RA