Reference Report

Reference
Citation	Pappu, K.S., Chen, R., Middlebrooks, B.W., Woo, C., Heberlein, U., Mardon, G. (2003). Mechanism of hedgehog signaling during Drosophila eye development. Development 130(13): 3053--3062. (Export to RIS)
FlyBase ID	FBrf0160839
Publication Type	Research paper
PubMed ID	12756186
PubMed Abstract	Although Hedgehog (Hh) signaling is essential for morphogenesis of the Drosophila eye, its exact link to the network of tissue-specific genes that regulate retinal determination has remained elusive. In this report, we demonstrate that the retinal determination gene eyes absent (eya) is the crucial link between the Hedgehog signaling pathway and photoreceptor differentiation. Specifically, we show that the mechanism by which Hh signaling controls initiation of photoreceptor differentiation is to alleviate repression of eya and decapentaplegic (dpp) expression by the zinc-finger transcription factor Cubitus interruptus (Ci(rep)). Furthermore, our results suggest that stabilized, full length Ci (Ci(act)) plays little or no role in Drosophila eye development. Moreover, while the effects of Hh are primarily concentration dependent in other tissues, hh signaling in the eye acts as a binary switch to initiate retinal morphogenesis by inducing expression of the tissue-specific factor Eya.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (13)
	ci⁹⁴ ci^+t16 dpp^Scer\UAS.cSa Ecol\lacZ^hh-P30 ey^Scer\UAS.cHa eya^Scer\UAS.cPa hh^P30 hh^Scer\UAS.cCa Scer\GAL4^30A Scer\GAL4^ey.PB Scer\GAL80^αTub84B.PL smo^D16 so^Scer\UAS.cPa
Constructs (8)
	P{ci^+t16} P{GAL4-ey.B} P{tubP-GAL80} P{UAS-dpp.S} P{UAS-ey.H} P{UAS-eya.P} P{UAS-hh.C} P{UAS-so.P}
Genes (13)
	ci dac dpp Ecol\lacZ elav ey eya hh Scer\GAL4 Scer\GAL80 sens smo so
Insertions (2)
	P{GawB}30A P{PZ}hh^P30