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Citation
Piacentini, L., Fanti, L., Berloco, M., Perrini, B., Pimpinelli, S. (2003). Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin.  J. Cell Biol. 161(4): 707--714.
FlyBase ID
FBrf0160846
Publication Type
Research paper
Abstract

Heterochromatin protein 1 (HP1) is a conserved nonhistone chromosomal protein, which is involved in heterochromatin formation and gene silencing in many organisms. In addition, it has been shown that HP1 is also involved in telomere capping in Drosophila. Here, we show a novel striking feature of this protein demonstrating its involvement in the activation of several euchromatic genes in Drosophila. By immunostaining experiments using an HP1 antibody, we found that HP1 is associated with developmental and heat shock-induced puffs on polytene chromosomes. Because the puffs are the cytological phenotype of intense gene activity, we did a detailed analysis of the heat shock-induced expression of the HSP70 encoding gene in larvae with different doses of HP1 and found that HP1 is positively involved in Hsp70 gene activity. These data significantly broaden the current views of the roles of HP1 in vivo by demonstrating that this protein has multifunctional roles.

PubMed ID
PubMed Central ID
PMC2199350 (PMC) (EuropePMC)
Related Publication(s)
Note

Is HP1 an RNA detector that functions both in repression and activation?
Kellum, 2003, J. Cell Biol. 161(4): 671--672 [FBrf0160667]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Cell Biol.
    Title
    Journal of Cell Biology
    Publication Year
    1966-
    ISBN/ISSN
    0021-9525
    Data From Reference
    Alleles (6)
    Genes (9)
    Transgenic Constructs (1)