Reference Report

Reference
Citation	Schenck, A., Bardoni, B., Langmann, C., Harden, N., Mandel, J.L., Giangrande, A. (2003). CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein. Neuron 38(6): 887--898. (Export to RIS)
FlyBase ID	FBrf0160918
Publication Type	Research paper
PubMed ID	12818175
PubMed Abstract	Neuronal plasticity requires actin cytoskeleton remodeling and local protein translation in response to extracellular signals. Rho GTPase pathways control actin reorganization, while the fragile X mental retardation protein (FMRP) regulates the synthesis of specific proteins. Mutations affecting either pathway produce neuronal connectivity defects in model organisms and mental retardation in humans. We show that CYFIP, the fly ortholog of vertebrate FMRP interactors CYFIP1 and CYFIP2, is specifically expressed in the nervous system. CYFIP mutations affect axons and synapses, much like mutations in dFMR1 (the Drosophila FMR1 ortholog) and in Rho GTPase dRac1. CYFIP interacts biochemically and genetically with dFMR1 and dRac1. Finally, CYFIP acts as a dRac1 effector that antagonizes FMR1 function, providing a bridge between signal-dependent cytoskeleton remodeling and translation.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (3)
	Df(3L)Ar14-8 Df(3R)ea Tp(3;Y)B150
Alleles (14)
	Fmr1^EP3517 Fmr1^Δ113M Rac1^N17.Scer\UAS Rac1^V12.Scer\UAS Scer\GAL4^elav-C155 Scer\GAL4^GMR.PF Sra-1^5.2 Sra-1^8.1 Sra-1^35.1 Sra-1^70.1 Sra-1^85.1 Sra-1^EP3267 Sra-1^Scer\UAS.cSa Sra-1^unspecified
Constructs (3)
	P{GAL4-ninaE.GMR} P{UAS-CYFIP.S} P{UAS-Rac1.V12}
Genes (8)
	dlg1 Fas2 FK506-bp1 Fmr1 futsch Rac1 Scer\GAL4 Sra-1
Insertions (3)
	P{EP}Fmr1^EP3517 P{EP}Sra-1^EP3267 P{GawB}elav^C155