Reference Report

Reference
Citation	Sears, H.C., Kennedy, C.J., Garrity, P.A. (2003). Macrophage-mediated corpse engulfment is required for normal Drosophila CNS morphogenesis. Development 130(15): 3557--3565. (Export to RIS)
FlyBase ID	FBrf0160936
Publication Type	Research paper
PubMed ID	12810602
PubMed Abstract	Cell death plays an essential role in development, and the removal of cell corpses presents an important challenge for the developing organism. Macrophages are largely responsible for the clearance of cell corpses in Drosophila melanogaster and mammalian systems. We have examined the developmental requirement for macrophages in Drosophila and find that macrophage function is essential for central nervous system (CNS) morphogenesis. We generate and analyze mutations in the Pvr locus, which encodes a receptor tyrosine kinase of the PDGF/VEGF family that is required for hemocyte migration. We find that loss of Pvr function causes the mispositioning of glia within the CNS and the disruption of the CNS axon scaffold. We further find that inhibition of hemocyte development or of Croquemort, a receptor required for macrophage-mediated corpse engulfment, causes similar CNS defects. These data indicate that macrophage-mediated clearance of cell corpses is required for proper morphogenesis of the Drosophila CNS.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (7)
	Ab(2)Pvr^KO8 Df(2L)TE29Aa-11 Df(3L)H99 Dp(2;2)Pvr^KO1 Dp(2;2)Pvr^KO2 Dp(2;2)Pvr^KO4 Dp(2;2)Pvr^KO10
Alleles (29)
	crq^{dsRNA.681-1203} crq^{dsRNA.1209-1737} Ecol\lacZ^sli.1.0HV Pvr^{4.5.Scer\SceI.RS} Pvr⁷²⁹ Pvr⁹⁵⁷ Pvr¹⁰⁹⁸ Pvr⁴¹⁸⁷ Pvr⁵³⁶³ Pvr⁵⁵⁰⁸ Pvr⁷⁵⁰⁸ Pvr⁷⁸⁰⁵ Pvr⁷⁸³⁷ Pvr⁷⁸⁷³ Pvr⁸⁶³⁰ Pvr⁹⁷⁴² Pvr^DN.Scer\UAS Pvr^KO1.3' Pvr^KO1.5' Pvr^KO2.3' Pvr^KO2.5' Pvr^KO4.3' Pvr^KO4.5' Pvr^KO10.3' Pvr^KO10.5' Scer\GAL4^gcm-rA87.P Scer\GAL4^sim.P3.7 srp^neo45 w^+mW.hs
Constructs (4)
	P{FRT(w⁺.Pvr^{4.5.Scer\SceI.RS})} P{GAL4-sim.3.7} P{sli(1.0)-lacZ} P{UAS-Pvr.DN}
Genes (11)
	crq Ecol\lacZ Fas2 gcm Pvr Pxn repo Scer\GAL4 srp w wrapper
Insertions (1)
	P{GawB}gcm^rA87.P
Transcripts (1)
	Scer\GAL4^gcm-rA87.PRA