Reference Report

Reference
Citation	Shimojima, T., Okada, M., Nakayama, T., Ueda, H., Okawa, K., Iwamatsu, A., Handa, H., Hirose, S. (2003). Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor. Genes Dev. 17(13): 1605--1616. (Export to RIS)
FlyBase ID	FBrf0160948
Publication Type	Research paper
PubMed ID	12815073
PubMed Abstract	Chromatin structure plays a critical role in the regulation of transcription. Drosophila GAGA factor directs chromatin remodeling to its binding sites. We show here that Drosophila FACT (facilitates chromatin transcription), a heterodimer of dSPT16 and dSSRP1, is associated with GAGA factor through its dSSRP1 subunit, binds to a nucleosome, and facilitates GAGA factor-directed chromatin remodeling. Moreover, genetic interactions between Trithorax-like encoding GAGA factor and spt16 implicate the GAGA factor-FACT complex in expression of Hox genes Ultrabithorax, Sex combs reduced, and Abdominal-B. Chromatin immunoprecipitation experiments indicated the presence of the GAGA factor-FACT complex in the regulatory regions of Ultrabithorax and Abdominal-B. These data illustrate a crucial role of FACT in the modulation of chromatin structure for the regulation of gene expression.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Aberrations (1)
	Df(3L)Aprt-21
Alleles (5)
	dre4^{Hsp83.T:Zzzz\His6} Trl^13C Trl^{Hsp83.T:Zzzz\FLAG} Ubx¹ Ubx¹³⁰
Constructs (2)
	P{Hsp83-GAGA.FLAG} P{Hsp83-spt16.His}
Genes (9)
	Abd-B Aprt CG13937 dre4 Ssrp T:Zzzz\FLAG T:Zzzz\His6 Trl Ubx