Reference Report

Reference
Citation	Srivastava, A., Bell, J.B. (2003). Further developmental roles of the Vestigial/Scalloped transcription complex during wing development in Drosophila melanogaster. Mech. Dev. 120(5): 587--596. (Export to RIS)
FlyBase ID	FBrf0160975
Publication Type	Research paper
PubMed ID	12782275
PubMed Abstract	The Drosophila homologue of the human TEF-1 gene, scalloped (sd), is required for wing development. The SD protein forms part of a transcriptional activation complex with the protein encoded by vestigial (vg) that, in turn, activates target genes important for wing formation. One sd function involves a regulatory feedback loop with vg and wingless (wg) that is essential in this process. The dorsal-ventral (D/V) margin-specific expression of wg is lost in sd mutant wing discs while the hinge-specific expression appears normal. In the context of wing development, a VG::sdTEA domain fusion produces a protein that mimics the wild-type SD/VG complex and restores the D/V boundary-specific expression of wg in a sd mutant background. Further, targeted expression of wg at the D/V boundary in the wing disc was able to partially rescue the sd mutant phenotype. This infers that sd could function in either the maintenance or induction of wg at the D/V border. Another functional role for sd is the establishment of sensory organ precursors (SOP) of the peripheral nervous system at the wing margin. Thus, the relationship between sd and senseless (sens) in the development of these cells is also examined, and it appears that sd must be functional for proper sens expression, and ultimately, for sensory organ precursor development.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Alleles (10)
	pan^ΔN.Scer\UAS Scer\GAL4^bbg-C96 Scer\GAL4^dpp.blk1 Scer\GAL4^vg.boundary sd::vg^{Scer\UAS.sdTEA} sd^58d sd^ETX4 sens^Ly-1 sens^Scer\UAS.cNa wg^{Scer\UAS.T:Ecol\lacZ}
Constructs (6)
	P{GAL4-dpp.blk1} P{UAS-pan.dTCFΔN} P{UAS-sens.N} P{UAS-vg::sd.TEA} P{UAS-wg.T:Ecol\lacZ} P{vg-GAL4.boundary}
Genes (8)
	pan Scer\GAL4 sd sd::vg sens T:Ecol\lacZ vg wg
Insertions (2)
	P{GawB}bbg^C96 P{lArB}sd^ETX4