Reference Report

Reference
Citation	Szuplewski, S., Kottler, B., Terracol, R. (2003). The Drosophila bZIP transcription factor Vrille is involved in hair and cell growth. Development 130(16): 3651--3662. (Export to RIS)
FlyBase ID	FBrf0160992
Publication Type	Research paper
PubMed ID	12835382
PubMed Abstract	Vri is closely related to bZIP transcription factors involved in growth or cell death. vri clonal and overexpression analyses revealed defects at the cellular level. vri clones in the adult cuticle contain smaller cells with atrophic bristles. The phenotypes are strictly cell autonomous. Clones induced in the eye precursor cells lead to individuals with smaller eyes and reduced number of ommatidia with an abnormal morphology and shorter photoreceptor cell stalks. Overexpression of vri is anti-proliferative in embryonic dorsal epidermis and in imaginal discs, and induces apoptosis. On the wing surface, larger cells with multiple trichomes are observed, suggesting cytoskeletal defects. In salivary glands, vri overexpression leads to smaller cells and organs. We also show that vri is involved in locomotion and flight and interacts genetically with genes encoding actin-binding proteins. The phenotypes observed are consistent with the hypothesis that vri is required for normal cell growth and proliferation via the regulation of the actin cytoskeleton.
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Secondary IDs
Language of Publication	English
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Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (2)
	Df(2L)tkv2 Df(2L)vri^5R1.5
Alleles (48)
	a¹ Actn⁸ Actn¹⁴ Actn^G0077 bt¹ CG14024^5R1.5 CycE^Scer\UAS.cLa dap^Scer\UAS.cLa kst⁰¹³¹⁸ Pten^Scer\UAS.cGb Rbf¹¹ Rbf¹⁴ Rbf^Scer\UAS.cDa Scer\GAL4^A9 Scer\GAL4^Act5C.PP Scer\GAL4^Bx-MS1096 Scer\GAL4^C-765 Scer\GAL4^en-e16E Scer\GAL4^ey.PH Scer\GAL4^F4 Scer\GAL4^hs.PB Scer\GAL4^pnr-MD237 Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} Scer\GAL4^vg.PM stg^Scer\UAS.cNa vri^1.Scer\UAS vri¹ vri^2.Scer\UAS vri² vri^5R1.5 vri^5R5.7 vri^5R5.24 vri^5R7.2 vri^5R8.4 vri^BG01569 vri^EY01490 vri^k03801 vri^k05901 vri^k09602 vri^k09713 vri^k11805 vri^KG01220 vri^KG03762 vri^KG10174 vri^unspecified w^+mC w^mC.5R1.5 w^mC.5R7.2
Constructs (16)
	P{3'lacW.5R5.24} P{5'lacW.5R1.5} P{5'lacW.5R7.2} P{GAL4-Act5C(FRT.CD2).P} P{GAL4-Act5C(-FRT).P} P{GAL4-ey.H} P{GAL4-Hsp70.PB} P{GAL4-vg.M} P{lacW} P{UAS-CycE.L} P{UAS-dap.L} P{UAS-Pten.Gb} P{UAS-Rbf.D} P{UAS-stg.N} P{UAS-vri.1} P{UAS-vri.2}
Genes (15)
	a Actn Bsg25D bt Bub1 CG14024 CycE dap kst Pten Rbf Scer\GAL4 stg vri w
Insertions (22)
	P{3'lacW.5R5.24}vri^5R5.24 P{5'lacW.5R1.5}vri^5R1.5 P{5'lacW.5R7.2}vri^5R7.2 P{?lacW}vri^5R5.7 P{?lacW}vri^5R8.4 P{en2.4-GAL4}e16E P{EPgy2}vri^EY01490 P{GAL4}A9 P{GawB}Bx^MS1096 P{GawB}C-765 P{GawB}F4 P{GawB}pnr^MD237 P{GT1}vri^BG01569 P{lacW}vri^k05901 P{SUPor-P}vri^KG01220 P{SUPor-P}vri^KG03762 P{SUPor-P}vri^KG10174 P{UAS-vri.1}6 P{UAS-vri.1}9 P{UAS-vri.1}13 P{UAS-vri.1}14 P{UAS-vri.2}8