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Citation
Yamashita, Y.M., Jones, D.L., Fuller, M.T. (2003). Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome.  Science 301(5639): 1547--1550.
FlyBase ID
FBrf0161562
Publication Type
Research paper
Abstract
Stem cell self-renewal can be specified by local signals from the surrounding microenvironment, or niche. However, the relation between the niche and the mechanisms that ensure the correct balance between stem cell self-renewal and differentiation is poorly understood. Here, we show that dividing Drosophila male germline stem cells use intracellular mechanisms involving centrosome function and cortically localized Adenomatous Polyposis Coli tumor suppressor protein to orient mitotic spindles perpendicular to the niche, ensuring a reliably asymmetric outcome in which one daughter cell remains in the niche and self-renews stem cell identity, whereas the other, displaced away, initiates differentiation.
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PubMed Central ID
Related Publication(s)
Review
Orienting stem cells.
Wallenfang and Matunis, 2003, Science 301(5639): 1490--1491 [FBrf0161560]
Stem cells in the news: cNN and APC make headlines.
McCartney and Peifer, 2003, Dev. Cell 5(4): 532--534 [FBrf0167470]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference
    Aberrations (1)
    Alleles (11)
    Genes (10)
    Transgenic Constructs (3)