Reference Report

Reference
Citation	Kenyon, K.L., Ranade, S.S., Curtiss, J., Mlodzik, M., Pignoni, F. (2003). Coordinating proliferation and tissue specification to promote regional identity in the Drosophila head. Dev. Cell 5(3): 403--414. (Export to RIS)
FlyBase ID	FBrf0162063
Publication Type	Research paper
PubMed ID	12967560
PubMed Abstract	The Decapentaplegic and Notch signaling pathways are thought to direct regional specification in the Drosophila eye-antennal epithelium by controlling the expression of selector genes for the eye (Eyeless/Pax6, Eyes absent) and/or antenna (Distal-less). Here, we investigate the function of these signaling pathways in this process. We find that organ primordia formation is indeed controlled at the level of Decapentaplegic expression but critical steps in regional specification occur earlier than previously proposed. Contrary to previous findings, Notch does not specify eye field identity by promoting Eyeless expression but it influences eye primordium formation through its control of proliferation. Our analysis of Notch function reveals an important connection between proliferation, field size, and regional specification. We propose that field size modulates the interaction between the Decapentaplegic and Wingless pathways, thereby linking proliferation and patterning in eye primordium development.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Aberrations (1)
	Df(1)N-54l9
Alleles (20)
	Avic\GFP^Scer\UAS.cUa Avic\GFP^{Scer\UAS.T:SV40\nls2} CycE^Scer\UAS.cLa Dll⁰¹⁰⁹² dpp¹⁰⁶³⁸ dpp^d12 dpp^d14 dpp^hr4 dpp^hr56 dpp^Scer\UAS.cSa Ecol\lacZ^dpp.BS3.0 N^DN.Scer\UAS N^ECN.Scer\UAS N^l1N-ts1 N^l1N-ts2 Scer\GAL4^Dll-md23 Scer\GAL4^ey.PB Scer\GAL4^ey.PH Ser^DN.Scer\UAS wg^l-12
Constructs (10)
	P{BS3.0} P{GAL4-ey.B} P{GAL4-ey.H} P{UAS-CycE.L} P{UAS-dpp.S} P{UAS-GFP.nls} P{UAS-GFP.U} P{UAS-N.DN} P{UAS-N.ECN} P{UAS-Ser.DN}
Genes (14)
	Avic\GFP ct CycE Dll dpp Ecol\lacZ ey eya His3 N Scer\GAL4 Ser T:SV40\nls2 wg
Insertions (3)
	P{GawB}Dll^md23 P{PZ}Dll⁰¹⁰⁹² P{PZ}dpp¹⁰⁶³⁸