Reference Report

Reference
Citation	Agaisse, H., Petersen, U.M., Boutros, M., Mathey-Prevot, B., Perrimon, N. (2003). Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev. Cell 5(3): 441--450. (Export to RIS)
FlyBase ID	FBrf0162064
Publication Type	Research paper
PubMed ID	12967563
PubMed Abstract	To characterize the features of JAK/STAT signaling in Drosophila immune response, we have identified totA as a gene that is regulated by the JAK/STAT pathway in response to septic injury. We show that septic injury triggers the hemocyte-specific expression of upd3, a gene encoding a novel Upd-like cytokine that is necessary for the JAK/STAT-dependent activation of totA in the Drosophila counterpart of the mammalian liver, the fat body. In addition, we demonstrate that totA activation also requires the NF-KB-like Relish pathway, indicating that fat body cells integrate the activity of NF-KB and JAK/STAT signaling pathways upon immune response. This study reveals that, in addition to the pattern recognition receptor-mediated NF-KB-dependent immune response, Drosophila undergoes a complex systemic response that is mediated by the production of cytokines in blood cells, a process that is similar to the acute phase response in mammals.
DOI
Related Publication(s)
Review	A cytokine in the Drosophila stress response. Hultmark and Ekengren, 2003, Dev. Cell 5(3): 360--361 [FBrf0162059]
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
ISBN/ISSN
Data from Reference
Aberrations (1)
	Df(1)os1A2
Alleles (16)
	Avic\GFP^Scer\UAS.cUa dome^{ΔCYT.Scer\UAS} hop²⁵ hop³² hop^Tum imd^Scer\UAS.cGa os¹ os^upd-4 Rel^{dsRNA.Scer\UAS} Rel^E20 Scer\GAL4^c273 Scer\GAL4^Hml.PG Scer\GAL4^upd3.PA Scer\GAL4^yolk Tak1¹ upd3^{dsRNA.Scer\UAS}
Constructs (8)
	P{Hml-GAL4.G} P{UAS-dome.ΔCYT} P{UAS-GFP.U} P{UAS-imd.G} P{UAS-Rel.dsRNA} P{UAS-upd3.dsRNA} P{upd3-GAL4.A} P{yolk-GAL4}
Genes (15)
	Avic\GFP Dana\Om(1E) dome Dpt Drs hop imd os Rel Scer\GAL4 Stat92E Tak1 TotA upd2 upd3
Insertions (1)
	P{GawB}c273