Reference Report

Reference
Citation	Aldaz, S., Morata, G., Azpiazu, N. (2003). The Pax-homeobox gene eyegone is involved in the subdivision of the thorax of Drosophila. Development 130(18): 4473--4482. (Export to RIS)
FlyBase ID	FBrf0162073
Publication Type	Research paper
PubMed ID	12900462
PubMed Abstract	The eyegone (eyg) gene is known to be involved in the development of the eye structures of Drosophila. We show that eyg and its related gene, twin of eyegone (toe), are also expressed in part of the anterior compartment of the adult mesothorax (notum). We report experiments concerning the role of these genes in the notum. In the absence of eyg function the anterior-central region does not develop, whereas ectopic activity of either eyg or toe induces the formation of the anterior-central pattern in the posterior or lateral region of the notum. These results demonstrate that eyg and toe play a role in the genetic subdivision of the notum, although the experiments indicate that eyg exerts the principal function. However, by itself the Eyg product cannot induce the formation of notum patterns; its thoracic function requires co-expression with the Iroquois (Iro) genes. We show that the restriction of eyg activity to the anterior-central region of the wing disc is achieved by the antagonistic regulatory activities of the Iro and pnr genes, which promote eyg expression, and those of the Hh and Dpp pathways, which act as repressors. We argue that eyg is a subordinate gene of the Iro genes, and that pnr mediates their thoracic patterning function. The activity of eyg gives rise to a new notum subdivision that acts upon the pre-extant one generated by the Iro genes and pnr. As a result the notum becomes subdivided into four distinct genetic domains.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (2)
	Df(3L)iro-2 Df(3L)iro-DFM1
Alleles (26)
	ara^Scer\UAS.cGa BacA\p35^Scer\UAS.cHa Ecol\lacZ^en-Xho25 Ecol\lacZ^esg-G66 Ecol\lacZ^neur-A101 eyg^20MD1 eyg^gv5 eyg^SA1 eyg^SA2 eyg^Scer\UAS.cAa Mad^B1 pnr^Scer\UAS.cHa ptc¹⁶ Scer\GAL4^455.2 Scer\GAL4^ap-md544 Scer\GAL4^EM461 Scer\GAL4^eyg-gv5 Scer\GAL4^MD-638 Scer\GAL4^MS248 Scer\GAL4^pnr-MD237 Scer\GAL4^Ubx.PdC Scer\GAL4^ush-MD751 smo³ tkv⁴ tkv^{Q199D.Scer\UAS.T:Ivir\HA1} toe^Scer\UAS.cAa
Constructs (7)
	P{GAL4-lacZ-Ubx(-FRT).dC} P{UAS-ara.G} P{UAS-eyg.A} P{UAS-p35.H} P{UAS-pnr.H} P{UAS-tkv^Q199D} P{UAS-toe.A}
Genes (16)
	ara BacA\p35 CG32102 Ecol\lacZ en esg eyg Mad neur pnr ptc Scer\GAL4 smo T:Ivir\HA1 tkv toe
Insertions (11)
	P{en-lacZ(Xho)}en^Xho25 P{GAL4}eyg^gv5 P{GAL4}MD-638 P{GawB}455.2 P{GawB}ap^md544 P{GawB}EM461 P{GawB}MS248 P{GawB}pnr^MD237 P{GawB}ush^MD751 P{lacZ}eyg^20MD1 P{lArB}neur^A101
Transcripts (3)
	Scer\GAL4^EM461RA Scer\GAL4^MD-638RA Scer\GAL4^MS248RA