Reference Report

Reference
Citation	Wesley, C.S., Mok, L.P. (2003). Regulation of Notch signaling by a novel mechanism involving suppressor of hairless stability and carboxyl terminus-truncated Notch. Mol. Cell. Biol. 23(16): 5581--5593. (Export to RIS)
FlyBase ID	FBrf0162239
Publication Type	Research paper
PubMed ID	12897132
PubMed Abstract	Different amounts of Suppressor of Hairless (SuH)-dependent Notch (N) signaling is often used during animal development to produce two different tissues from a population of equipotent cells. During Drosophila melanogaster embryogenesis, cells with high amounts of this signaling differentiate the larval epidermis whereas cells with low amounts, or none, differentiate the central nervous system (CNS). The mechanism by which SuH-dependent N signaling is increased or decreased in these different cells is obscure. The developing epidermis is known to get enriched for the full-length N (NFull) and the developing CNS for the carboxyl terminus-truncated N (NdeltaCterm). Results described here indicate that this differential accumulation of N receptors is part of a mechanism that would promote SuH-dependent N signaling in the developing epidermis but suppress it in the developing CNS. This mechanism involves SuH-dependent stability of NFull, NFull-dependent accumulation of SuH, stage specific stability of SuH, and NdeltaCterm-dependent loss of SuH and NFull.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mol. Cell. Biol.
Title	Molecular and Cellular Biology
Publication Year	1981-
ISBN/ISSN	0270-7306
Data from Reference
Alleles (17)
	Dl^hs.-I Dl^hs.PL H^Scer\UAS.cGa N^1-2155.hs N^{1-2155.Scer\UAS} N^60g11 N^1791-2155.hs N^{1791-2155.Scer\UAS} N^{1893-2155.Scer\UAS} N^Hsp70Bb.PL N^{intra.hs.Scer\UAS} Scer\GAL4^Act.PU Scer\GAL4^arm.PS Scer\GAL4^da.G32 Scer\GAL4^hs.PB Su(H)^del47 Su(H)^dsRNA.cWa
Constructs (8)
	P{GAL4-arm.S} P{GAL4-da.G32} P{GAL4-Hsp70.PB} P{UAS-H.G} P{UAS-hs.N.intra.1790} P{UAS-N.1-2155} P{UAS-N.1791-2155} P{UAS-N.1893-2155}
Genes (10)
	Dl E(spl)m3-HLH H N RpL40 RpS27A Scer\GAL4 Su(H) Ubi-p5E Ubi-p63E
Natural transposons (1)
	P-element