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Citation
Rawson, R.B. (2003). The SREBP pathway: insights from Insigs and insects.  Nat. Rev. Mol. Cell Biol. 4(8): 631--640.
FlyBase ID
FBrf0162253
Publication Type
Review
Abstract

Animal cells coordinate lipid homeostasis by end-product feedback regulation of transcription. The control occurs through the proteolytic release of transcriptionally active sterol regulatory element binding proteins (SREBPs) from intracellular membranes. This feedback system has unexpected features that are found in all cells. Here, we consider recently discovered components of the regulatory machinery that govern SREBP processing, as well as studies in Drosophila that indicate an ancient role for the SREBP pathway in integrating membrane composition and lipid biosynthesis.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Rev. Mol. Cell Biol.
    Title
    Nature Reviews. Molecular Cell Biology
    Publication Year
    2000-
    ISBN/ISSN
    1471-0072
    Data From Reference
    Genes (9)