Reference Report

Reference
Citation	Johnston, L.A., Sanders, A.L. (2003). Wingless promotes cell survival but constrains growth during Drosophila wing development. Nat. Cell Biol. 5(9): 827--833. (Export to RIS)
FlyBase ID	FBrf0162258
Publication Type	Research paper
PubMed ID	12942089
PubMed Abstract	During animal development, organs grow to a fixed size and shape. Organ development typically begins with a rapid growth phase followed by a gradual decline in growth rate as the organ matures, but the regulation of either stage of growth remains unclear. The Wnt/Wingless (Wg) proteins are critical for patterning most animal organs, have diverse effects on development and have been proposed to promote organ growth. Here we report that contrary to this view, Wg activity actually constrains wing growth during Drosophila melanogaster wing development. In addition, we demonstrate that Wg is required for wing cell survival, particularly during the rapid growth phase of wing development. We propose that the cell-survival- and growth-constraining activities of Wg function to sculpt and delimit final wing size as part of its overall patterning programme.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nat. Cell Biol.
Title	Nature Cell Biology
Publication Year	1999-
ISBN/ISSN	1465-7392 1476-4679
Data from Reference
Alleles (16)
	arm^{Δ.Scer\UAS.T:Ivir\HA1} arr² Avic\GFP^Scer\UAS.cUa BacA\p35^Scer\UAS.cHa ftz^{Orc1.T:Avic\GFP,T:Hsap\MYC} fz2^unspecified fz^unspecified pan^ΔN.Scer\UAS Scer\GAL4^Act5C.PP Scer\GAL4^AH658 Scer\GAL4^bbg-C96 Scer\GAL4^C10 Scer\GAL4^C-765 Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} Scer\GAL4^αTub84B.PL wg^Scer\UAS.cLa
Constructs (9)
	P{GAL4-Act5C(FRT.CD2).P} P{GAL4-Act5C(-FRT).P} P{Orc1-ftz-GFP-Myc.A} P{tubP-GAL4} P{UAS-arm.Δ.flu} P{UAS-GFP.U} P{UAS-p35.H} P{UAS-pan.dTCFΔN} P{UAS-wg.L}
Genes (21)
	arm arr Avic\GFP BacA\p35 Dll E2f ftz fz fz2 hth nub pan Scer\GAL4 sens stg T:Avic\GFP T:Hsap\MYC T:Ivir\HA1 tsh vg wg
Insertions (4)
	P{GAL4}AH658 P{GawB}bbg^C96 P{GawB}C10 P{GawB}C-765