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Citation
Biessmann, H., Mason, J.M. (2003). Telomerase-independent mechanisms of telomere elongation.  Cell. Molec. Life Sci. 60(11): 2325--2333.
FlyBase ID
FBrf0167384
Publication Type
Review
Abstract

The ends of linear chromosomes must be elongated in a DNA-replication-independent fashion. For chromosome end elongation the majority of eukaryotes use a specialized reverse transcriptase, telomerase, which adds a short, tandemly repeated DNA sequence motif to chromosome ends. Chromosome elongation can also be achieved, however, by mechanisms other than telomerase. Such elongation events have been detected under conditions where telomerase has been inactivated experimentally and in the few organisms that naturally lack telomerase. We will summarize current knowledge on these telomerase-independent elongation mechanisms in yeast and mammalian cells and will discuss in more detail the telomere elongation mechanism by retrotransposons in Drosophila melanogaster.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell. Molec. Life Sci.
    Title
    Cellular and molecular life sciences. CMLS
    Publication Year
    1997-
    ISBN/ISSN
    1420-682X
    Data From Reference
    Alleles (1)
    Genes (9)
    Natural transposons (2)
    Insertions (1)