Reference Report

Reference
Citation	Barros, C.S., Phelps, C.B., Brand, A.H. (2003). Drosophila nonmuscle myosin II promotes the asymmetric segregation of cell fate determinants by cortical exclusion rather than active transport. Dev. Cell 5(6): 829--840. (Export to RIS)
FlyBase ID	FBrf0167483
Publication Type	Research paper
PubMed ID	14667406
PubMed Abstract	Cell fate diversity can be achieved through the asymmetric segregation of cell fate determinants. In the Drosophila embryo, neuroblasts divide asymmetrically and in a stem cell fashion. The determinants Prospero and Numb localize in a basal crescent and are partitioned from neuroblasts to their daughters (GMCs). Here we show that nonmuscle myosin II regulates asymmetric cell division by an unexpected mechanism, excluding determinants from the apical cortex. Myosin II is activated by Rho kinase and restricted to the apical cortex by the tumor suppressor Lethal (2) giant larvae. During prophase and metaphase, myosin II prevents determinants from localizing apically. At anaphase and telophase, myosin II moves to the cleavage furrow and appears to "push" rather than carry determinants into the GMC. Therefore, the movement of myosin II to the contractile ring not only initiates cytokinesis but also completes the partitioning of cell fate determinants from the neuroblast to its daughter.
DOI
Related Publication(s)
Review	Myosins motor Miranda. Kiehart, 2003, Mol. Cell 12(6): 1346--1347 [FBrf0174947]
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
ISBN/ISSN
Data from Reference
Alleles (8)
	l(2)gl¹ l(2)gl^3A.Scer\UAS Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} sqh¹ sqh^E20.E21 sqh^{RLC.T:Avic\GFP-S65T} zip¹ zip^{Scer\UAS.T:Avic\GFP}
Constructs (5)
	P{matα4-GAL-VP16} P{sqh-E20E21} P{sqh-GFP.RLC} P{UAS-l(2)gl.3A} P{UAS-zip.GFP}
Genes (14)
	Act5C Act42A aPKC baz l(2)gl mira numb pros Rho1 Scer\GAL4 sqh T:Avic\GFP T:Hsim\VP16 zip
Insertions (1)
	P{}sqh¹