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Reference Report
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| Citation | Voas, M.G., Rebay, I. (2004). Signal integration during development: insights from the Drosophila eye. Dev. Dyn. 229(1): 162--175. (Export to RIS) | ||
| FlyBase ID | FBrf0167489 | ||
| Publication Type | Review | ||
| PubMed ID | 14699588 | ||
| PubMed Abstract | The Drosophila eye is a highly ordered epithelial tissue composed of approximately 750 subunits called ommatidia arranged in a reiterated hexagonal pattern. At higher resolution, observation of the constituent photoreceptors, cone cells, and pigment cells of the eye reveals a highly ordered mosaic of amazing regularity. This relatively simple organization belies the repeated requirement for spatially and temporally coordinated inputs from the Hedgehog (Hh), Wingless (Wg), Decapentaplegic (Dpp), JAK-STAT, Notch, and receptor tyrosine kinase (RTK) signaling pathways. This review will discuss how signaling inputs from the Notch and RTK pathways, superimposed on the developmental history of a cell, facilitate context-specific and appropriate cell fate specification decisions in the developing fly eye. Lessons learned from investigating the combinatorial signal integration strategies underlying Drosophila eye development will likely reveal cell-cell communication paradigms relevant to many aspects of invertebrate and mammalian development. Developmental Dynamics 229:162-175, 2004. | ||
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| Language of Publication | English | ||
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Parent Publication
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| Publication Type | Journal | ||
| Abbreviation | Dev. Dyn. | ||
| Title | Developmental Dynamics | ||
| Publication Year | 1992- | ||
| ISBN/ISSN | 1058-8388 | ||
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Data from Reference
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| Genes (39)
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