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Citation
Zelhof, A.C., Koundakjian, E., Scully, A.L., Hardy, R.W., Pounds, L. (2003). Mutation of the photoreceptor specific homeodomain gene Pph13 results in defects in phototransduction and rhabdomere morphogenesis.  Development 130(18): 4383--4392.
FlyBase ID
FBrf0167494
Publication Type
Research paper
Abstract

The expression and organization of the phototransduction signaling proteins into a specialized light-sensing organelle, the rhabdomere, is required for photoreceptor cells to detect light. We report the characterization of the mutant Pph13(hazy). Pph13 is a homeodomain transcription factor expressed only in photoreceptor cells. Pph13 expression correlates with the differentiation and not specification of photoreceptor cells. In agreement with its expression profile, we find Pph13 is required for both rhabdomere morphogenesis and for the proper detection of light. In addition, we demonstrate that Pph13 exerts its effect by the regulation of photoreceptor specific gene expression.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference
    Aberrations (12)
    Alleles (5)
    Genes (24)
    Sequence Features (1)
    Natural transposons (1)
    Experimental Tools (1)
    Transgenic Constructs (2)