Reference Report

Reference
Citation	Lim, J., Choi, K.W. (2003). Bar homeodomain proteins are anti-proneural in the Drosophila eye: transcriptional repression of atonal by Bar prevents ectopic retinal neurogenesis. Development 130(24): 5965--5974. (Export to RIS)
FlyBase ID	FBrf0167507
Publication Type	Research paper
PubMed ID	14573515
PubMed Abstract	Atonal (Ato)/Math (Mammalian atonal homolog) family proneural proteins are key regulators of neurogenesis in both vertebrates and invertebrates. In the Drosophila eye, Ato is essential for the generation of photoreceptor neurons. Ato expression is initiated at the anterior ridge of the morphogenetic furrow but is repressed in the retinal precursor cells behind the furrow to prevent ectopic neurogenesis. We show that Ato repression is mediated by the conserved homeobox proteins BarH1 and BarH2. Loss of Bar causes cell-autonomous ectopic Ato expression, resulting in excess photoreceptor clusters. The initial ommatidial spacing at the furrow occurs normally in the absence of Bar, suggesting that the ectopic neurogenesis within Bar mutant clones is not due to the lack of Notch (N)-dependent lateral inhibition. Targeted misexpression of Bar is sufficient to repress ato expression. Furthermore, we provide evidence that Bar represses ato expression at the level of transcription without affecting the expression of an ato activator, Cubitus interruptus (Ci). Thus, we propose that Bar is essential for transcriptional repression of ato and the prevention of ectopic neurogenesis behind the furrow.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(1)B
Alleles (8)
	B-H1^Scer\UAS.cSa B-H2^Scer\UAS.cSa Ecol\lacZ^ato.3'F.5.8 Ecol\lacZ^ato.5'F.7.2 Ecol\lacZ^ato.5'F.9.3 lz^gal4 Scer\GAL4^dpp.blk1 Scer\GAL4^lz-gal4
Constructs (6)
	P{ato-lacZ.3'F:5.8} P{ato-lacZ.5'F:7.2} P{ato-lacZ.5'F:9.3} P{GAL4-dpp.blk1} P{UAS-B-H1.S} P{UAS-B-H2.S}
Genes (16)
	arm ato B-H1 B-H2 boss ci Dl dlg1 E(spl)m8-HLH Ecol\lacZ elav lz rl sca Scer\GAL4 sens
Insertions (3)
	P{GawB}lz^gal4 P{UAS-B-H1.S}M12 P{UAS-B-H2.S}F11