Reference Report

Reference
Citation	Rawlins, E.L., Lovegrove, B., Jarman, A.P. (2003). Echinoid facilitates Notch pathway signalling during Drosophila neurogenesis through functional interaction with Delta. Development 130(26): 6475--6484. (Export to RIS)
FlyBase ID	FBrf0167521
Publication Type	Research paper
PubMed ID	14627723
PubMed Abstract	The Notch intercellular signalling pathway is important throughout development, and its components are modulated by a variety of cellular and molecular mechanisms. Ligand and receptor trafficking are tightly controlled, although context-specific regulation of this is incompletely understood. We show that during sense organ precursor specification in Drosophila, the cell adhesion molecule Echinoid colocalises extensively with the Notch ligand, Delta, at the cell membrane and in early endosomes. Echinoid facilitates efficient Notch pathway signalling. Cultured cell experiments suggest that Echinoid is associated with the cis-endocytosis of Delta, and is therefore linked to the signalling events that have been shown to require such Delta trafficking. Consistent with this, overexpression of Echinoid protein causes a reduction in Delta level at the membrane and in endosomes. In vivo and cell culture studies suggest that homophilic interaction of Echinoid on adjacent cells is necessary for its function.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (3)
	Df(1)ase-1 Df(1)sc-B57 Df(2L)ed-dp
Alleles (25)
	aos^Δ7 ase^Scer\UAS.cBa Dl^B2 Dl^hs.PB Dl^unspecified ed^4.4 ed^4.12 ed^6.1 ed^{hs.T:Hsap\MYC} ed^{hs.T:Zzzz\FLAG} ed^k01102 ed^lH23 ed^Scer\UAS.cBa ed^{Scer\UAS.T:Avic\GFP} Egfr^f2 fng^{ADD.Scer\UAS.T:Hsap\MYC} H¹ hk¹ N^55e11 N^hs.PB sc^Scer\UAS.cCa sca^BP2 Scer\GAL4^dpp.blk1 Scer\GAL4^sca-109-68 Scer\GAL4^sca-537.4
Constructs (6)
	P{UAS-ADD-fng.MYC} P{UAS-ase.B} P{UAS-ed::GFP} P{UAS-ed.B} P{UAS-l(1)sc.C} P{UAS-sc.C}
Genes (20)
	ac aos ase Dl ed Egfr elav Fas2 fng H hk Hrs N sc sca Scer\GAL4 sens T:Avic\GFP T:Hsap\MYC T:Zzzz\FLAG
Insertions (3)
	P{GawB}sca^109-68 P{GawB}sca^537.4 P{lacW}ed^k01102