Reference Report

Reference
Citation	Giraldez, A.J., Cohen, S.M. (2003). Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development. Development 130(26): 6533--6543. (Export to RIS)
FlyBase ID	FBrf0167523
Publication Type	Research paper
PubMed ID	14660542
PubMed Abstract	Tissue growth during animal development depends on the coordination of cell proliferation and cell death. The EGF-receptor/MAPK, Hedgehog, Dpp, Wingless (Wg) and Notch signaling pathways have been implicated in growth control in the developing Drosophila wing. In this report, we examine the effects of Notch and Wg on growth in terms of cell proliferation and cell survival. Reduction of Wg signaling impaired compartment and clonal growth, and increased cell death. Inhibition of apoptosis in cells deficient for Wg signaling only partially rescued the clone growth defect, suggesting that Wg is also required to promote cell proliferation. This is supported by the finding that ectopic expression of Wg caused over-proliferation of cells in the proximal wing. Localized activation of Notch had non-autonomous effects on cell proliferation. However, only part of this effect was attributable to Notch-dependent induction of Wg, suggesting that other Notch-inducible signaling molecules contribute to the control of cell proliferation in the wing.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (20)
	arr² Axn^S044230 BacA\p35^Scer\UAS.cHa Ecol\lacZ^puc-E69 fz2^{ECD.GPI.Scer\UAS.T:Hsap\MYC} M(2)53¹ N^{intra.GS.Scer\UAS} nkd^{Scer\UAS.T:Hsap\MYC} Notum^{GT.Scer\UAS.T:Hsap\GALNT3} Notum^{S237A.Scer\UAS} puc^E69 puc^Scer\UAS.cMa pygo^S28 RpS3² Scer\GAL4^ap-md544 Scer\GAL4^dpp.blk1 Scer\GAL4^αTub84B.PL vg^83b27-R wg^l-17 wg^Scer\UAS.cLa
Constructs (9)
	P{GAL4-dpp.blk1} P{tubP-GAL4} P{UAS-fz2(ECD)-GPI} P{UAS-N.intra.GS} P{UAS-nkd.myc} P{UAS-Notum.GT} P{UAS-p35.H} P{UAS-puc.M} P{UAS-wg.L}
Genes (21)
	arr Axn BacA\p35 ct CycE Dll Ecol\lacZ fz2 M(2)53 N nkd Notum nub puc pygo RpS3 Scer\GAL4 T:Hsap\GALNT3 T:Hsap\MYC vg wg
Insertions (3)
	P{A92}puc^E69 P{GawB}ap^md544 P{lacW}Axn^S044230