Reference Report

Reference
Citation	Jefferis, G.S., Vyas, R.M., Berdnik, D., Ramaekers, A., Stocker, R.F., Tanaka, N.K., Ito, K., Luo, L. (2004). Developmental origin of wiring specificity in the olfactory system of Drosophila. Development 131(1): 117--130. (Export to RIS)
FlyBase ID	FBrf0167525
Publication Type	Research paper
PubMed ID	14645123
PubMed Abstract	In both insects and mammals, olfactory receptor neurons (ORNs) expressing specific olfactory receptors converge their axons onto specific glomeruli, creating a spatial map in the brain. We have previously shown that second order projection neurons (PNs) in Drosophila are prespecified by lineage and birth order to send their dendrites to one of approximately 50 glomeruli in the antennal lobe. How can a given class of ORN axons match up with a given class of PN dendrites? Here, we examine the cellular and developmental events that lead to this wiring specificity. We find that, before ORN axon arrival, PN dendrites have already created a prototypic map that resembles the adult glomerular map, by virtue of their selective dendritic localization. Positional cues that create this prototypic dendritic map do not appear to be either from the residual larval olfactory system or from glial processes within the antennal lobe. We propose instead that this prototypic map might originate from both patterning information external to the developing antennal lobe and interactions among PN dendrites.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (12)
	Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} repo^M1B Scer\FLP1^ey.PN Scer\GAL4⁴⁵⁵¹ Scer\GAL4^elav-C155 Scer\GAL4^Gad1.3.098 Scer\GAL4^GH146 Scer\GAL4^lilli-189Y Scer\GAL4^MJ94 Scer\GAL4^Mz19 Scer\GAL4^repo-M1B Scer\GAL80^αTub84B.PL
Constructs (5)
	P{ey-FLP.N} P{Gad1-GAL4.3.098} P{tubP-GAL80} P{UAS(-FRT)CD8-GFP} P{UAS-mCD8::GFP.L}
Genes (10)
	CadN elav Fas2 Gad1 Mmus\Cd8a repo Scer\FLP1 Scer\GAL4 Scer\GAL80 T:Avic\GFP
Insertions (8)
	P{GAL4}4551 P{GAL4}repo^M1B P{GawB}198Y P{GawB}elav^C155 P{GawB}GH146 P{GawB}lilli^189Y P{GawB}MJ94 P{GawB}Mz19
Transcripts (5)
	Scer\GAL4⁴⁵⁵¹RA Scer\GAL4^Gad1.3.098RA Scer\GAL4^MJ94RA Scer\GAL4^Mz19RA Scer\GAL4^repo-M1BRA