Reference Report

Reference
Citation	Zhang, W., Jin, Y., Ji, Y., Girton, J., Johansen, J., Johansen, K.M. (2003). Genetic and phenotypic analysis of alleles of the Drosophila chromosomal JIL-1 kinase reveals a functional requirement at multiple developmental stages. Genetics 165(3): 1341--1354. (Export to RIS)
FlyBase ID	FBrf0167636
Publication Type	Research paper
PubMed ID	14668387
PubMed Abstract	In this study we provide a cytological and genetic characterization of the JIL-1 locus in Drosophila. JIL-1 is an essential chromosomal tandem kinase and in JIL-1 null animals chromatin structure is severely perturbed. Using a range of JIL-1 hypomorphic mutations, we show that they form an allelic series. JIL-1 has a strong maternal effect and JIL-1 activity is required at all stages of development, including embryonic, larval, and pupal stages. Furthermore, we identified a new allele of JIL-1, JIL-1(h9), that encodes a truncated protein missing COOH-terminal sequences. Remarkably, the truncated JIL-1 protein can partially restore viability without rescuing the defects in polytene chromosome organization. This suggests that sequences within this region of JIL-1 play an important role in establishing and/or maintaining normal chromatin structure. By analyzing the effects of JIL-1 mutations we provide evidence that JIL-1 function is necessary for the normal progression of several developmental processes at different developmental stages such as oogenesis and segment specification. We propose that JIL-1 may exert such effects by a general regulation of chromatin structure affecting gene expression.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (9)
	Df(3L)h9 Df(3L)h76 Df(3L)JIL-1^z60 Df(3L)lxd6 Df(3L)lxd8 Df(3L)vin2 Df(3L)vin3 Df(3L)vin4 Df(3L)vin5
Alleles (14)
	brm² JIL-1^EP3657 JIL-1^h9 JIL-1^Scim JIL-1^z2 JIL-1^z28 JIL-1^z60 l(3)68Ad^l55 l(3)68Ae^l58 l(3)68Ag¹ l(3)68Ag^l1 l(3)01239⁰¹²³⁹ Mocs1^h9 trx^E2
Genes (11)
	brm CG6279 CG7839 JIL-1 l(3)68Ad l(3)68Ae l(3)68Ag l(3)01239 Mocs1 Sod trx
Insertions (3)
	P{3'EP}JIL-1^z60 P{?EP}JIL-1^z28 P{EP}JIL-1^EP3657