Reference Report

Reference
Citation	Voas, M.G., Rebay, I. (2003). The novel plant homeodomain protein rhinoceros antagonizes Ras signaling in the Drosophila eye. Genetics 165(4): 1993--2006. (Export to RIS)
FlyBase ID	FBrf0167656
Publication Type	Research paper
PubMed ID	14704181
PubMed Abstract	The sequential specification of cell fates in the Drosophila eye requires repeated activation of the epidermal growth factor receptor (EGFR)/Ras/MAP kinase (MAPK) pathway. Equally important are the multiple layers of inhibitory regulation that prevent excessive or inappropriate signaling. Here we describe the molecular and genetic analysis of a previously uncharacterized gene, rhinoceros (rno), that we propose functions to restrict EGFR signaling in the eye. Loss of rno results in the overproduction of photoreceptors, cone cells, and pigment cells and a corresponding reduction in programmed cell death, all phenotypes characteristic of hyperactivated EGFR signaling. Genetic interactions between rno and multiple EGFR pathway components support this hypothesis. rno encodes a novel but evolutionarily conserved nuclear protein with a PHD zinc-finger domain, a motif commonly found in chromatin-remodeling factors. Future analyses of rno will help to elucidate the regulatory strategies that modulate EGFR signaling in the fly eye.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (4)
	Df(3L)rH321 Df(3L)rH321Δ26 Df(3L)XKR845 Df(3L)XZB970
Alleles (19)
	aos⁰⁵⁸⁴⁵ aos^Scer\UAS.cMa aos^Δ7 ebi^1-334.GMR Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Ras85D^V12.sev rno¹ rno² rno³ rno⁴ rno⁵ rno⁶ rno⁷ rno^{Scer\UAS.T:Hsap\MYC} rno^unspecified Scer\GAL4^GMR.PF Scer\GAL4^hs.2sev Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} svp⁰⁷⁸⁴²
Constructs (8)
	P{GAL4-Act5C(FRT.CD2).P} P{GAL4-Hsp70.sev} P{GAL4-ninaE.GMR} P{GMR-ebi.1-334} P{sevRas1.V12} P{UAS-argos.M} P{UAS-mCD8::GFP.L} P{UAS-rno.MYC}
Genes (14)
	aos arm ct ebi elav Mmus\Cd8a Ras85D rno ro salm Scer\GAL4 svp T:Avic\GFP T:Hsap\MYC
Insertions (3)
	P{GAL4-Hsp70.sev}K24 P{PZ}aos⁰⁵⁸⁴⁵ P{PZ}svp⁰⁷⁸⁴²