A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Reference Report

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Citation Senger, K., Armstrong, G.W., Rowell, W.J., Kwan, J.M., Markstein, M., Levine, M. (2004). Immunity regulatory DNAs share common organizational features in Drosophila.  Mol. Cell 13(1): 19--32. (Export to RIS)
FlyBase ID FBrf0167880
Publication Type Research paper
PubMed ID 14731391
PubMed Abstract Infection results in the rapid activation of immunity genes in the Drosophila fat body. Two classes of transcription factors have been implicated in this process: the REL-containing proteins, Dorsal, Dif, and Relish, and the GATA factor Serpent. Here we present evidence that REL-GATA synergy plays a pervasive role in the immune response. SELEX assays identified consensus binding sites that permitted the characterization of several immunity regulatory DNAs. The distribution of REL and GATA sites within these DNAs suggests that most or all fat-specific immunity genes contain a common organization of regulatory elements: closely linked REL and GATA binding sites positioned in the same orientation and located near the transcription start site. Aspects of this "regulatory code" are essential for the immune response. These results suggest that immunity regulatory DNAs contain constrained organizational features, which may be a general property of eukaryotic enhancers.
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Language of Publication English
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Publication Type Journal
Abbreviation Mol. Cell
Title Molecular Cell
Publication Year 1997-
ISBN/ISSN 1097-2765 1097-4164
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