Open Close
Reference
Citation
Senger, K., Armstrong, G.W., Rowell, W.J., Kwan, J.M., Markstein, M., Levine, M. (2004). Immunity regulatory DNAs share common organizational features in Drosophila.  Mol. Cell 13(1): 19--32.
FlyBase ID
FBrf0167880
Publication Type
Research paper
Abstract

Infection results in the rapid activation of immunity genes in the Drosophila fat body. Two classes of transcription factors have been implicated in this process: the REL-containing proteins, Dorsal, Dif, and Relish, and the GATA factor Serpent. Here we present evidence that REL-GATA synergy plays a pervasive role in the immune response. SELEX assays identified consensus binding sites that permitted the characterization of several immunity regulatory DNAs. The distribution of REL and GATA sites within these DNAs suggests that most or all fat-specific immunity genes contain a common organization of regulatory elements: closely linked REL and GATA binding sites positioned in the same orientation and located near the transcription start site. Aspects of this "regulatory code" are essential for the immune response. These results suggest that immunity regulatory DNAs contain constrained organizational features, which may be a general property of eukaryotic enhancers.

PubMed ID
PubMed Central ID
Related Publication(s)
Note

Learning the codes of fly immunity.
Bettencourt and Ip, 2004, Mol. Cell 13(1): 1--2 [FBrf0167879]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mol. Cell
    Title
    Molecular Cell
    Publication Year
    1997-
    ISBN/ISSN
    1097-2765 1097-4164
    Data From Reference