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Englund, C., Loren, C.E., Grabbe, C., Varshney, G.K., Deleuil, F., Hallberg, B., Palmer, R.H. (2003). Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion.  Nature 425(6957): 512--516.
FlyBase ID
FBrf0167923
Publication Type
Research paper
Abstract

The Drosophila melanogaster gene Anaplastic lymphoma kinase (Alk) is homologous to mammalian Alk, a member of the Alk/Ltk family of receptor tyrosine kinases (RTKs). We have previously shown that the Drosophila Alk RTK is crucial for visceral mesoderm development during early embryogenesis. Notably, observed Alk visceral mesoderm defects are highly reminiscent of the phenotype reported for the secreted molecule Jelly belly (Jeb). Here we show that Drosophila Alk is the receptor for Jeb in the developing visceral mesoderm, and that Jeb binding stimulates an Alk-driven, extracellular signal-regulated kinase-mediated signalling pathway, which results in the expression of the downstream gene duf (also known as kirre)--needed for muscle fusion. This new signal transduction pathway drives specification of the muscle founder cells, and the regulation of Duf expression by the Drosophila Alk RTK explains the visceral-mesoderm-specific muscle fusion defects observed in both Alk and jeb mutant animals.

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Review

Developmental biology: Partners united.
Freeman, 2003, Nature 425(6957): 468--469 [FBrf0173096]

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nature
    Title
    Nature
    Publication Year
    1869-
    ISBN/ISSN
    0028-0836
    Data From Reference
    Alleles (8)
    Genes (8)
    Physical Interactions (3)
    Insertions (1)
    Experimental Tools (2)
    Transgenic Constructs (3)