Reference Report

Reference
Citation	De Joussineau, C., Soule, J., Martin, M., Anguille, C., Montcourrier, P., Alexandre, D. (2003). Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila. Nature 426(6966): 555--559. (Export to RIS)
FlyBase ID	FBrf0167931
Publication Type	Research paper
PubMed ID	14654840
PubMed Abstract	Drosophila thoracic mechanosensory bristles originate from cells that are singled out from 'proneural' groups of competent epithelial cells. Neural competence is restricted to individual sensory organ precursors (SOPs) by Delta/Notch-mediated 'lateral inhibition', whereas other cells in the proneural field adopt an epidermal fate. The precursors of the large macrochaetes differentiate separately from individual proneural clusters that comprise about 20-30 cells or as heterochronic pairs from groups of more than 100 cells, whereas the precursors of the small regularly spaced microchaetes emerge from even larger proneural fields. This indicates that lateral inhibition might act over several cell diameters; it was difficult to reconcile with the fact that the inhibitory ligand Delta is membrane-bound until the observation that SOPs frequently extend thin processes offered an attractive hypothesis. Here we show that the extension of these planar filopodia--a common attribute of wing imaginal disc cells--is promoted by Delta and that their experimental suppression reduces Notch signalling in distant cells and increases bristle density in large proneural groups, showing that these membrane specializations mediate long-range lateral inhibition.
DOI
Related Publication(s)
Erratum	corrigendum: Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila. De Joussineau et al., 2004, Nature 428(6982): 445 [FBrf0179003]
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Alleles (12)
	Dl^RF Dl^Scer\UAS.cHa Dl^{Scer\UAS.T:Avic\GFP} Ecol\lacZ^Dl.-4.3 Ecol\lacZ^{E(spl).-1166+87} Hsap\EZR^{1-280.Scer\UAS.T:Avic\GFP} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^klu-G410 Scer\GAL4^neur-P72 Scer\GAL4^sca-537.4 Scer\GAL4^{Scer\FRT.Gal80.αTub84B} Scer\GAL4^{Scer\FRT.Rnor\CD2.αTub84B}
Constructs (8)
	P{DlE1(-4.3)-lacZ} P{GAL4-αTub84B(FRT.CD2).P} P{m8-lacZ} P{UAS-Dl::GFP} P{UAS-Dl.H} P{UAS-ezrin.1-280.GFP} P{UAS-mCD8::GFP.L} P{αTub84B(FRT.Gal80.y⁺)GAL4.C}
Genes (9)
	Dl E(spl)m8-HLH Ecol\lacZ elav Hsap\EZR Mmus\Cd8a N Scer\GAL4 T:Avic\GFP
Insertions (3)
	P{GAL4}klu^G410 P{GAL4}neur^P72 P{GawB}sca^537.4