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Citation
Hipfner, D.R., Cohen, S.M. (2003). The Drosophila Sterile-20 Kinase Slik Controls Cell Proliferation and Apoptosis during Imaginal Disc Development.  PLoS Biol. 1(2): e35.
FlyBase ID
FBrf0167985
Publication Type
Research paper
Abstract
Cell proliferation and programmed cell death are closely controlled during animal development. Proliferative stimuli generally also induce apoptosis, and anti-apoptotic factors are required to allow net cell proliferation. Genetic studies in Drosophila have led to identification of a number of genes that control both processes, providing new insights into the mechanisms that coordinate cell growth, proliferation, and death during development and that fail to do so in diseases of cell proliferation. We present evidence that the Drosophila Sterile-20 kinase Slik promotes cell proliferation and controls cell survival. At normal levels, Slik provides survival cues that prevent apoptosis. Cells deprived of Slik activity can grow, divide, and differentiate, but have an intrinsic survival defect and undergo apoptosis even under conditions in which they are not competing with normal cells for survival cues. Like some oncogenes, excess Slik activity stimulates cell proliferation, but this is compensated for by increased cell death. Tumor-like tissue overgrowth results when apoptosis is prevented. We present evidence that Slik acts via Raf, but not via the canonical ERK pathway. Activation of Raf can compensate for the lack of Slik and support cell survival, but activation of ERK cannot. We suggest that Slik mediates growth and survival cues to promote cell proliferation and control cell survival during Drosophila development.
PubMed ID
PubMed Central ID
PMC261876 (PMC) (EuropePMC)
Related Publication(s)
Review
silk gene controls cell growth and survival.
Hipgner and Cohen, 2003, PLoS Biol. 1(2): e43 [FBrf0173077]
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Secondary IDs
  • FBrf0173079
Language of Publication
English
Additional Languages of Abstract
Parent Publication
Publication Type
Journal
Abbreviation
PLoS Biol.
Title
PLoS Biology
Publication Year
2003-
ISBN/ISSN
1545-7885 1544-9173
Data From Reference
Alleles (17)
Genes (10)
Physical Interactions (1)
Cell Lines (1)
Insertions (4)
Experimental Tools (1)
Transgenic Constructs (8)