Reference Report

Reference
Citation	Chyb, S., Dahanukar, A., Wickens, A., Carlson, J.R. (2003). Drosophila Gr5a encodes a taste receptor tuned to trehalose. Proc. Natl. Acad. Sci. U.S.A. 100(Supplement 2): 14526--14530. (Export to RIS)
FlyBase ID	FBrf0168006
Publication Type	Research paper
PubMed ID	14523229
PubMed Abstract	Recent studies have suggested that Drosophila taste receptors are encoded by a family of G protein-coupled receptor genes comprising at least 56 members. One of these genes, Gr5a, has been shown by genetic analysis to be required by the fly for behavioral and sensory responses to a sugar, trehalose. Here, we show that Gr5a is expressed in neurons of taste sensilla located on the labellum and legs. Expression is observed in most if not all labellar sensilla and suggests that many taste neurons express more than one receptor. We demonstrate by heterologous expression in a Drosophila S2 cell line that Gr5a encodes a receptor tuned to trehalose. This is the first functional expression of an invertebrate taste receptor.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Alleles (3)
	Gr5a^MtnA.PC Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^Gr5a.8.5
Constructs (2)
	P{Gr5a-GAL4.8.5} P{UAS-mCD8::GFP.L}
Genes (5)
	Gr5a Gr64f Mmus\Cd8a Scer\GAL4 T:Avic\GFP
Sequence features (1)
	Tre_Gr5a_promoter