Reference Report

Reference
Citation	McGuire, S.E., Le, P.T., Osborn, A.J., Matsumoto, K., Davis, R.L. (2003). Spatiotemporal rescue of memory dysfunction in Drosophila. Science 302(5651): 1765--1768. (Export to RIS)
FlyBase ID	FBrf0168032
Publication Type	Research paper
PubMed ID	14657498
PubMed Abstract	We have developed a method for temporal and regional gene expression targeting (TARGET) in Drosophila and show the simultaneous spatial and temporal rescue of a memory defect. The transient expression of the rutabaga-encoded adenylyl cyclase in the mushroom bodies of the adult brain was necessary and sufficient to rescue the rutabaga memory deficit, which rules out a developmental brain defect in the etiology of this deficit and demonstrates an acute role for rutabaga in memory formation in these neurons. The TARGET system offers general utility in simultaneously addressing issues of when and where gene products are required.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Science
Title	Science
Publication Year	1895-
ISBN/ISSN	0036-8075
Data from Reference
Alleles (7)
	rut²⁰⁸⁰ rut^Scer\UAS.cZa Scer\GAL4^c739 Scer\GAL4^c747 Scer\GAL4^elav-C155 Scer\GAL4^Mef2.247 Scer\GAL80^ts.αTub84B
Constructs (4)
	P{Mef2-GAL4.247} P{tubP-GAL80^ts} P{UAS-rut.M} P{UAS-rut.Z}
Genes (3)
	rut Scer\GAL4 Scer\GAL80
Insertions (3)
	P{GawB}c747 P{GawB}elav^C155 P{GawB}Hr39^c739