|Citation||Wilson, R.I., Turner, G.C., Laurent, G. (2004). Transformation of olfactory representations in the Drosophila antennal lobe. Science 303(5656): 366--370. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||Molecular genetics has revealed a precise stereotypy in the projection of primary olfactory sensory neurons onto secondary neurons. A major challenge is to understand how this mapping translates into odor responses in these second-order neurons. We investigated this question in Drosophila using whole-cell recordings in vivo. We observe that monomolecular odors generally elicit responses in large ensembles of antennal lobe neurons. Comparison of odor-evoked activity from afferents and postsynaptic neurons in the same glomerulus revealed that second-order neurons display broader tuning and more complex responses than their primary afferents. This indicates a major transformation of odor representations, implicating lateral interactions within the antennal lobe.|
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|Language of Publication||English|
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