Reference Report

Reference
Citation	de la Cova, C., Abril, M., Bellosta, P., Gallant, P., Johnston, L.A. (2004). Drosophila myc regulates organ size by inducing cell competition. Cell 117(1): 107--116. (Export to RIS)
FlyBase ID	FBrf0174444
Publication Type	Research paper
PubMed ID	15066286
PubMed Abstract	Experiments in both vertebrates and invertebrates have illustrated the competitive nature of growth and led to the idea that competition is a mechanism of regulating organ and tissue size. We have assessed competitive interactions between cells in a developing organ and examined their effect on its final size. We show that local expression of the Drosophila growth regulator dMyc, a homolog of the c-myc protooncogene, induces cell competition and leads to the death of nearby wild-type cells in developing wings. We demonstrate that cell competition is executed via induction of the proapoptotic gene hid and that both competition and hid function are required for the wing to reach an appropriate size when dMyc is expressed. Moreover, we provide evidence that reproducible wing size during normal development requires apoptosis. Modulating dmyc levels to create cell competition and hid-dependent cell death may be a mechanism used during normal development to control organ size.
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (2)
	Df(3L)H99 Df(3L)X14
Alleles (25)
	Avic\GFP^{S65T.Scer\UAS.T:SV40\nls2} BacA\p35^Scer\UAS.cHa Cdk4^Scer\UAS.cMa CycD^Scer\UAS.cDa dm^Scer\UAS.cZa dm^αTub84B.PBb Ecol\lacZ^{Act5C.PS.T:Zzzz\nls1} Ecol\lacZ^puc-E69 Ecol\lacZ^{Scer\FRT.Act5C.T:Zzzz\nls1} hep^r75 Pi3K92E^{Scer\UAS.T:Hsap\MYC} Rnor\CD2^hs.PJ RpL14¹ RpL14^Scer\UAS.cMa Scer\GAL4^Act5C.PP Scer\GAL4^C10 Scer\GAL4^dpp.blk1 Scer\GAL4^{Scer\FRT.Gal80.αTub84B} Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} Scer\GAL4^{Scer\FRT.αTub84B.PBb} Scer\GAL4^unspecified Scer\GAL4^αTub84B.PBb Scer\GAL4^αTub84B.PC Scer\GAL80^αTub84B.PC y^+t*
Constructs (17)
	P{Act5C(FRT.polyA)lacZ.nls1} P{Act5C(-FRT)lacZ.nls1} P{GAL4-Act5C(FRT.CD2).P} P{GAL4-Act5C(-FRT).P} P{GAL4-dpp.blk1} P{hsp70-CD2.J} P{UAS-Cdk4.M} P{UAS-CycD.D} P{UAS-dm.Z} P{UAS-GFP^S65T.nls} P{UAS-p35.H} P{UAS-RpL14.M} P{WT-Dp110} P{αTub84B(FRT.dm)GAL4.Bb} P{αTub84B(FRT.Gal80.y⁺)GAL4.C} P{αTub84B(-FRT)GAL4.Bb} P{αTub84B(-FRT)GAL4.C}
Genes (17)
	Avic\GFP BacA\p35 Cdk4 CycD dm Ecol\lacZ hep Pi3K92E Rnor\CD2 RpL14 Scer\GAL4 Scer\GAL80 T:Hsap\MYC T:SV40\nls2 T:Zzzz\nls1 W y
Insertions (3)
	P{A92}puc^E69 P{GawB}C10 P{lacW}RpL14¹