Reference Report

Reference
Citation	Moreno, E., Basler, K. (2004). dMyc transforms cells into super-competitors. Cell 117(1): 117--129. (Export to RIS)
FlyBase ID	FBrf0174445
Publication Type	Research paper
PubMed ID	15066287
PubMed Abstract	Overexpression of myc protooncogenes has been implicated in the genesis of many human tumors. Myc proteins seem to regulate diverse biological processes, but their role in tumorigenesis remains enigmatic. Here we use Drosophila imaginal discs to mimic situations in which cells with unequal levels of Myc protein are apposed and show that this invariably elicits a win/lose situation reminiscent of cell competition; cells with lower levels of dMyc are eliminated by apoptosis whereas cells with higher levels of dMyc over-proliferate. We find that this competitive behavior correlates with, and can be corrected by, the activation of the BMP/Dpp survival signaling pathway. Hence the heritable increase in dMyc levels causes cells to behave as "super-competitors" and reveals a novel mode of clonal expansion that causes, but also relies on, the killing of surrounding cells.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (4)
	Dp(1;1)Co T(1;2)sc^S2 Ts(1Lt;2Lt)sc^S2 Ts(1Rt;2Rt)sc^S2
Alleles (22)
	arm^{S10.Scer\UAS.T:Hsap\MYC} Avic\GFP^hs.PN BacA\p35^Scer\UAS.cHa btl::Egfr^{Scer\UAS.T:λ\cI-DD} dm^P0 dm^PG45 dm^αTub84B.PBb dpp^Scer\UAS.cRa Ecol\lacZ^brk.B40 Ecol\lacZ^puc-E69 Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX} puc^Scer\UAS.cMa put^Scer\UAS.cNa Rab5^Scer\UAS.cEa Ras85D^V12.Scer\UAS RpL19^unspecified Scer\GAL4^hh-Gal4 Scer\GAL4^{Scer\FRT.αTub84B.PBb} Scer\GAL4^αTub84B.PBb T:λ\cI^DD tkv^{Q253D.Scer\UAS.cNb} wg^{Scer\UAS.T:Ivir\HA1}
Constructs (15)
	H{UAS-dpp.R} P{brk-lacZ.B40} P{Dp110-CAAX} P{smo⁺,hsp70-GFP} P{UAS-arm.S10} P{UAS-Egfr.λtop} P{UAS-p35.H} P{UAS-puc.M} P{UAS-put.N} P{UAS-Rab5.E} P{UAS-Ras85D.V12} P{UAS-tkv.Q253D.Nb} P{UAS-wg.flu} P{αTub84B(FRT.dm)GAL4.Bb} P{αTub84B(-FRT)GAL4.Bb}
Genes (25)
	arm Avic\GFP BacA\p35 brk btl::Egfr decay dm dpp Ecol\lacZ en Ice Pi3K92E puc put Rab5 Ras85D RpL19 salm Scer\GAL4 T:Hsap\CAAX T:Hsap\MYC T:Ivir\HA1 T:λ\cI tkv wg
Insertions (4)
	P{A92}puc^E69 P{GAL4}hh^Gal4 P{GawB}dm^PG45 P{P-Sal}dm^P0