Reference Report

Reference
Citation	Tanaka, N.K., Awasaki, T., Shimada, T., Ito, K. (2004). Integration of chemosensory pathways in the Drosophila second-order olfactory centers. Curr. Biol. 14(6): 449--457. (Export to RIS)
FlyBase ID	FBrf0174482
Publication Type	Research paper
PubMed ID	15043809
PubMed Abstract	Behavioral responses to odorants require neurons of the higher olfactory centers to integrate signals detected by different chemosensory neurons. Recent studies revealed stereotypic arborizations of second-order olfactory neurons from the primary olfactory center to the secondary centers, but how third-order neurons read this odor map remained unknown.Using the Drosophila brain as a model system, we analyzed the connectivity patterns between second-order and third-order olfactory neurons. We first isolated three common projection zones in the two secondary centers, the mushroom body (MB) and the lateral horn (LH). Each zone receives converged information via second-order neurons from particular subgroups of antennal-lobe glomeruli. In the MB, third-order neurons extend their dendrites across various combinations of these zones, and axons of this heterogeneous population of neurons converge in the output region of the MB. In contrast, arborizations of the third-order neurons in the LH are constrained within a zone. Moreover, different zones of the LH are linked with different brain areas and form preferential associations between distinct subsets of antennal-lobe glomeruli and higher brain regions.MB is known to be an indispensable site for olfactory learning and memory, whereas LH function is reported to be sufficient for mediating direct nonassociative responses to odors. The structural organization of second-order and third-order neurons suggests that MB is capable of integrating a wide range of odorant information across glomeruli, whereas relatively little integration between different subsets of the olfactory signal repertoire is likely to occur in the LH.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Alleles (19)
	Avic\GFP^{S65T.Scer\UAS} Avic\GFP^T10 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^fru-NP0021 Scer\GAL4^Mz19 Scer\GAL4^Mz671 Scer\GAL4^NP0010 Scer\GAL4^NP0065 Scer\GAL4^NP0080 Scer\GAL4^NP0225 Scer\GAL4^NP1004 Scer\GAL4^NP3060 Scer\GAL4^NP3529 Scer\GAL4^NP5103 Scer\GAL4^NP5194 Scer\GAL4^NP5221 Scer\GAL4^NP5286 Scer\GAL4^NP6099 Scer\GAL4^NP7175
Constructs (1)
	P{UAS-mCD8::GFP.L}
Genes (4)
	Avic\GFP Mmus\Cd8a Scer\GAL4 T:Avic\GFP
Insertions (17)
	P{GawB}CG1358^NP5221 P{GawB}CG17834^NP5286 P{GawB}dve^NP3060 P{GawB}fru^NP0021 P{GawB}hfw^NP7175 P{GawB}Mz19 P{GawB}Mz671 P{GawB}NP0010 P{GawB}NP0065 P{GawB}NP0225 P{GawB}NP1004 P{GawB}NP3529 P{GawB}NP5194 P{GawB}NP6099 P{GawB}shn^NP0080 P{GawB}trol^NP5103 P{UAS-GFP.S65T}eg^T10
Transcripts (15)
	Scer\GAL4^fru-NP0021RA Scer\GAL4^Mz19RA Scer\GAL4^Mz671RA Scer\GAL4^NP0010RA Scer\GAL4^NP0065RA Scer\GAL4^NP0080RA Scer\GAL4^NP0225RA Scer\GAL4^NP1004RA Scer\GAL4^NP3060RA Scer\GAL4^NP3529RA Scer\GAL4^NP5103RA Scer\GAL4^NP5194RA Scer\GAL4^NP5286RA Scer\GAL4^NP6099RA Scer\GAL4^NP7175RA