Reference Report

Reference
Citation	Emerald, B.S., Cohen, S.M. (2004). Spatial and temporal regulation of the homeotic selector gene Antennapedia is required for the establishment of leg identity in Drosophila. Dev. Biol. 267(2): 462--472. (Export to RIS)
FlyBase ID	FBrf0174519
Publication Type	Research paper
PubMed ID	15013806
PubMed Abstract	Antennapedia is one of the homeotic selector genes required for specification of segment identity in Drosophila. Dominant mutations that ectopically express Antennapedia cause transformation of antenna to leg. Loss-of-function mutations cause partial transformation of leg to antenna. Here we examine the role of Antennapedia in the establishment of leg identity in light of recent advances in our understanding of antennal development. In Antennapedia mutant clones in the leg disc, Homothorax and Distal-less are coexpressed and act via spineless to transform proximal femur to antenna. Antennapedia is negatively regulated during leg development by Distal-less, spineless, and dachshund and this reduced Antennapedia expression is needed for the proper development of distal leg elements. These findings suggest that the temporal and spatial regulation of the homeotic selector gene Antennapedia in the leg disc is necessary for normal leg development in Drosophila.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Aberrations (1)
	Df(3R)ss-D114.4
Alleles (18)
	Antp^73b Antp^Ns-rvC3 Antp^Scer\UAS.cAa dac³ Dll³ Dll¹⁷ Dll^md23 Dll^Scer\UAS.cWa Ecol\lacZ^{Act5C.PS.T:Zzzz\nls1} Ecol\lacZ^arm.PV Scer\FLP1^{EBD.Scer\UAS.T:Hsap\ESR1} Scer\GAL4^Antp-10 Scer\GAL4^Antp-21 Scer\GAL4^dpp.blk1 Scer\GAL4^ptc-559.1 ss^a ss^D115.7 ss^Scer\UAS.A5
Constructs (7)
	P{Act5C(-FRT)lacZ.nls1} P{arm-lacZ.V} P{GAL4-dpp.blk1} P{UAS-Antp.A} P{UAS-Dll.W} P{UAS-Scer\FLP1.EBD} P{UAS-ss.A5}
Genes (12)
	al Antp dac dan Dll Ecol\lacZ hth Scer\FLP1 Scer\GAL4 ss T:Hsap\ESR1 T:Zzzz\nls1
Insertions (5)
	P{AntpP1-lacZ}8.4 P{GawB}Antp-10 P{GawB}Antp-21 P{GawB}Dll^md23 P{GawB}ptc^559.1