Reference Report

Reference
Citation	del Alamo Rodriguez, D., Terriente Felix, J., Diaz-Benjumea, F.J. (2004). The role of the T-box gene optomotor-blind in patterning the Drosophila wing. Dev. Biol. 268(2): 481--492. (Export to RIS)
FlyBase ID	FBrf0174525
Publication Type	Research paper
PubMed ID	15063183
PubMed Abstract	The development of the Drosophila wing is governed by the action of two morphogens encoded by the genes decapentaplegic (dpp; a member of the BMP gene family) and wingless (wg; a member of the WNT gene family), which promote cell proliferation and pattern the wing. Along the anterior/posterior (A/P) axis, the precise expression of decapentaplegic and its receptors is required for the transcriptional regulation of specific target genes. In the present work, we analyze the function of the T-box gene optomotor-blind (omb), a decapentaplegic target gene. The wings of optomotor-blind mutants have two apparently opposite phenotypes: the central wing is severely reduced and shows massive cell death, mainly in the distal-most wing, and the lateral wing shows extra cell proliferation. Here, we present genetic evidence that optomotor-blind is required to establish the graded expression of the decapentaplegic type I receptor encoded by the gene thick veins (tkv) to repress the expression of the gene master of thick veins and also to activate the expression of spalt (sal) and vestigial (vg), two decapentaplegic target genes. optomotor-blind plays a role in wing development downstream of decapentaplegic by controlling the expression of its receptor thick veins and by mediating the activation of target genes required for the correct development of the wing. The lack of optomotor-blind produces massive cell death in its expression domain, which leads to the mis-activation of the Notch pathway and the overproliferation of lateral wing cells.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Alleles (27)
	Avic\GFP^Scer\UAS.cUa BacA\p35^Scer\UAS.cHa bi^D4 bi^omb-1 bi^omb-3198 bi^omb-Gal4 bi^Scer\UAS.cBa Ecol\lacZ^ap-rK568 Ecol\lacZ^bi-Pol-1 Ecol\lacZ^brk-X47 Ecol\lacZ^caps-02937 Ecol\lacZ^Dad-P1883 Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^puc-E69 Ecol\lacZ^rN350 Ecol\lacZ^salm.10.2S:C Ecol\lacZ^sbb-k00702 Ecol\lacZ^tkv-k16713 Ecol\lacZ^trn-S064117 Ecol\lacZ^vg.806 N^l1N-ts1 puc^Scer\UAS.cMa Scer\GAL4^Act5C.PI Scer\GAL4^bi-omb-Gal4 Scer\GAL4^dpp.blk1 Scer\GAL4^nub-AC-62 Scer\GAL4^vg.int2.1
Constructs (10)
	P{Act5C-GAL4} P{BS3.0} P{GAL4-dpp.blk1} P{salm-lacZ.10.2S/C} P{UAS-GFP.U} P{UAS-omb.B} P{UAS-p35.H} P{UAS-puc.M} P{vg(806)-lacZ} P{vg(int2.1)-GAL4}
Genes (19)
	ap Avic\GFP BacA\p35 bi brk caps ci dpp Ecol\lacZ N nub puc salm sbb Scer\GAL4 tkv trn vg wg
Insertions (12)
	P{A92}puc^E69 P{GAL4}bi^omb-Gal4 P{GawB}nubbin-AC-62 P{lacW}bi^Pol-1 P{lacW}sbb^k00702 P{lacW}tkv^k16713 P{lacW}trn^S064117 P{lacZ}Dad^P1883 P{lacZ}rN350 P{PZ}ap^rK568 P{PZ}caps⁰²⁹³⁷ P{PZ}X47
Transcripts (8)
	Ecol\lacZ^puc-E69RA Ecol\lacZ^salm.10.2S:CRA Ecol\lacZ^sbb-k00702RA Ecol\lacZ^tkv-k16713RA Ecol\lacZ^trn-S064117RA Ecol\lacZ^vg.806RA Scer\GAL4^bi-omb-Gal4RA Scer\GAL4^nub-AC-62RA