Reference Report

Reference
Citation	Jhaveri, D., Saharan, S., Sen, A., Rodrigues, V. (2004). Positioning sensory terminals in the olfactory lobe of Drosophila by Robo signaling. Development 131(9): 1903--1912. (Export to RIS)
FlyBase ID	FBrf0174568
Publication Type	Research paper
PubMed ID	15056612
PubMed Abstract	Olfactory receptor neurons and the interneurons of the olfactory lobe are organized in distinct units called glomeruli. We have used expression patterns and genetic analysis to demonstrate that a combinatorial code of Roundabout (Robo) receptors act to position sensory terminals within the olfactory lobe. Groups of sensory neurons possess distinct blends of Robo and Robo3 and disruption of levels by loss-of-function or ectopic expression results in aberrant targeting. In the wild type, most of the neurons send collateral branches to the contralateral lobe. Our data suggests that guidance of axons across brain hemispheres is mediated by Slit-dependent Robo2 signaling. The location of sensory arbors at distinct positions within the lobe allows short-range interactions with projection neurons leading to formation of the glomeruli.
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (3)
	Df(2R)WMG Df(3R)p13 In(2LR)Gla
Alleles (26)
	Abl^EP3101 ato¹ ato^Scer\UAS.cJa Cdc42^V12.Scer\UAS comm^Scer\UAS.cKa lea^EP2582 lea^robo2-1 n-syb^{Scer\UAS.cEa.T:Avic\GFP} robo3¹ robo3^{Scer\UAS.T:Ivir\HA1,T:SS-wg} robo^Scer\UAS.cKa robo^{Scer\UAS.T:Ivir\HA1,T:SS-wg} Scer\GAL4^Act5C.PP Scer\GAL4^ato.3.6 Scer\GAL4^GH146 Scer\GAL4^loco.1.3 Scer\GAL4^lz-gal4 Scer\GAL4^Or22a.7.717 Scer\GAL4^Or47b.7.467 Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} Scer\GAL4^SG18.1 Scer\GAL4^sli.PS Scer\GAL80^αTub84B.PL sli^Scer\UAS.cKa wg^Gla-1 wg^Sp-1
Constructs (16)
	P{ato-GAL4.3.6} P{GAL4-Act5C(FRT.CD2).P} P{GAL4-Act5C(-FRT).P} P{GAL4-loco.1.3} P{GAL4-sli.S} P{Or22a-GAL4.7.717} P{Or47b-GAL4.7.467} P{tubP-GAL80} P{UAS-ato.J} P{UAS-Cdc42.V12} P{UAS-comm.K} P{UAS-n-syb-GFP.E} P{UAS-robo3.HA1} P{UAS-robo.HA1} P{UAS-robo.K} P{UAS-sli.K}
Genes (20)
	Abl ato Cdc42 comm lea loco lz n-syb Or22a Or47b repo robo robo3 Scer\GAL4 Scer\GAL80 sli T:Avic\GFP T:Ivir\HA1 T:SS-wg wg
Insertions (5)
	P{EP}Abl^EP3101 P{EP}lea^EP2582 P{GawB}GH146 P{GawB}lz^gal4 P{GawB}SG18.1
Transcripts (6)
	Scer\GAL4^ato.3.6RA Scer\GAL4^loco.1.3RA Scer\GAL4^lz-gal4RA Scer\GAL4^Or22a.7.717RA Scer\GAL4^Or47b.7.467RA Scer\GAL4^SG18.1RA