Reference Report

Reference
Citation	Weihe, U., Dorfman, R., Wernet, M.F., Cohen, S.M., Milan, M. (2004). Proximodistal subdivision of Drosophila legs and wings: the elbow-no ocelli gene complex. Development 131(4): 767--774. (Export to RIS)
FlyBase ID	FBrf0174589
Publication Type	Research paper
PubMed ID	14757638
PubMed Abstract	Appendages are thought to have arisen during evolution as outgrowths from the body wall of primitive bilateria. In Drosophila, subsets of body wall cells are set aside as appendage precursors through the action of secreted signaling proteins that direct localized expression of transcription factors. The Drosophila homeodomain protein Distal-less is expressed in the leg primordia and required for formation of legs, but not wings. The homeodomain protein Nubbin is expressed in the wing primordia and required for formation of wings, but not legs. Given that insect legs and wings have a common developmental and evolutionary origin, we sought to identify genes that underlie the specification of all appendage primordia. We present evidence that the zinc-finger proteins encoded by the elbow and no ocelli genes act in leg and wing primordia to repress body wall-specifying genes and thereby direct appendage formation.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(2L)el1
Alleles (17)
	elA¹ elB^3.3.1 elB^el-1 elB^EP2039 elB^GAL4 elB^Scer\UAS.cDa noc^d64 noc^el-1 noc^EP2000 noc^EP2173 noc^GAL4 noc^Scer\UAS.cDa Scer\GAL4^ap-md544 Scer\GAL4^dpp.blk1 Scer\GAL4^sd-SG29.1 sgg^Scer\UAS.cBa wg^{l-12.Scer\UAS}
Constructs (5)
	P{GAL4-dpp.blk1} P{UAS(-FRT)wg.ts} P{UAS-elB.D} P{UAS-noc.D} P{UAS-sgg.B}
Genes (10)
	Dll elA elB hth noc nub Scer\GAL4 sgg tsh wg
Insertions (7)
	P{EP}elB^EP2039 P{EP}noc^EP2000 P{EP}noc^EP2173 P{GAL4}elB^GAL4 P{GAL4}noc^GAL4 P{GawB}ap^md544 P{GawB}sd^SG29.1