Reference Report

Reference
Citation	Xu, H., Lee, S.J., Suzuki, E., Dugan, K.D., Stoddard, A., Li, H.S., Chodosh, L.A., Montell, C. (2004). A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen. EMBO J. 23(4): 811--822. (Export to RIS)
FlyBase ID	FBrf0174603
Publication Type	Research paper
PubMed ID	14963491
PubMed Abstract	The Drosophila visual system has provided a model to study phototransduction and retinal degeneration. To identify new candidate proteins that contribute to these processes, we conducted a genome-wide screen for genes expressed predominately in the eye, using DNA microarrays. This screen appeared to be comprehensive as it led to the identification of all 22 eye-enriched genes previously shown to function in phototransduction or implicated in retinal degeneration. In addition, we identified 93 eye-enriched genes whose roles have not been previously defined. One of the eye-enriched genes encoded a member of a large family of transmembrane proteins, referred to as tetraspanins. We created a null mutation in the eye-enriched tetraspanin, Sunglasses (Sun), which resulted in light-induced retinal degeneration. We found that the Sun protein was distributed primarily in lysosomes, and functioned in a long-known but poorly understood phenomenon of light-induced degradation of rhodopsin. We propose that lysosomal tetraspanins in mammalian cells may also function in the downregulation of rhodopsin and other G-protein-coupled receptors, in response to intense or prolonged agonist stimulation.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	EMBO J.
Title	The EMBO Journal
Publication Year	1982-
ISBN/ISSN	0261-4189
Data from Reference
Alleles (7)
	BacA\p35^unspecified gl^unspecified ninaE⁷ Tsp42Ej¹ Tsp42Ej^+t5.0 Tsp42Ej^EP2425 Tsp42Ej^{ninaE.T:Hsap\MYC}
Constructs (2)
	P{ninaE-Tsp42Ej.MYC} P{Tsp42Ej^+t5.0}
Genes (96)
	Ank2 Arr1 Arr2 BacA\p35 Cbp53E CdsA CG1561 CG2016 CG2650 CG3790 CG4306 CG4686 CG5027 CG6656 CG6870 CG6983 CG7059 CG7135 CG7220 CG8483 CG9150 CG9171 CG9427 CG9935 CG10257 CG12020 CG13356 CG13409 CG14464 CG15891 CG16857 CG17352 CG17739 CG33060 CG33061 CHIP Cpr49Ag Cpr57A Cpr72Ec Eaat2 Eip71CD Fbxl4 Fps85D Fs gl Gαq Gβ76C Gγ30A HisCl1 Hk inaC inaD inaF-D laza lectin-28C loqs ltd Mppe mre11 msta ninaA ninaB ninaC ninaE norpA ort Pis Pkn Pph13 PQBP1 Prx2540-2 Rab14 Rbp9 rdgA rdgC rdhB rdo retinin Rh2 Rh3 Rh4 Rh5 Rh6 RhoGDI rtp se Side Slob t T:Hsap\MYC Tequila trp trpl Tsp42Ej Ubpy und
Insertions (1)
	P{EP}Tsp42Ej^EP2425