Reference Report

Reference
Citation	Moore, A.W., Roegiers, F., Jan, L.Y., Jan, Y.N. (2004). Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecification. Genes Dev. 18(6): 623--628. (Export to RIS)
FlyBase ID	FBrf0174648
Publication Type	Research paper
PubMed ID	15075290
PubMed Abstract	The Drosophila external sensory organ forms in a lineage elaborating from a single precursor cell via a stereotypical series of asymmetric divisions. HAMLET transcription factor expression demarcates the lineage branch that generates two internal cell types, the external sensory neuron and thecogen. In HAMLET mutant organs, these internal cells are converted to external cells via an unprecedented cousin-cousin cell-fate respecification event. Conversely, ectopic HAMLET expression in the external cell branch leads to internal cell production. The fate-determining signals NOTCH and PAX2 act at multiple stages of lineage elaboration and HAMLET acts to modulate their activity in a branch-specific manner.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Alleles (11)
	Ecol\lacZ^A1-2-29 Ecol\lacZ^neur-A101 ham¹ ham^Scer\UAS.cMa Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} N^l1N-ts1 pon^{LD.Scer\UAS.T:Avic\GFP} Scer\GAL4^{neur-GAL4-A101} Scer\GAL4^sca-109-68 Scer\GAL80^αTub84B.PL sv^Scer\UAS.cKa
Constructs (4)
	P{tubP-GAL80} P{UAS-ham.M} P{UAS-mCD8::GFP.L} P{UAS-sv.K}
Genes (14)
	ct Ecol\lacZ elav ham Mmus\Cd8a N neur pon pros Scer\GAL4 Scer\GAL80 Su(H) sv T:Avic\GFP
Insertions (4)
	P{GawB}neur^GAL4-A101 P{GawB}sca^109-68 P{lacW}A1-2-29 P{lArB}neur^A101