Reference Report

Reference
Citation	Harbison, S.T., Yamamoto, A.H., Fanara, J.J., Norga, K.K., Mackay, T.F. (2004). Quantitative trait loci affecting starvation resistance in Drosophila melanogaster. Genetics 166(4): 1807--1823. (Export to RIS)
FlyBase ID	FBrf0174696
Publication Type	Research paper
PubMed ID	15126400
PubMed Abstract	The ability to withstand periods of scarce food resources is an important fitness trait. Starvation resistance is a quantitative trait controlled by multiple interacting genes and exhibits considerable genetic variation in natural populations. This genetic variation could be maintained in the face of strong selection due to a trade-off in resource allocation between reproductive activity and individual survival. Knowledge of the genes affecting starvation tolerance and the subset of genes that affect variation in starvation resistance in natural populations would enable us to evaluate this hypothesis from a quantitative genetic perspective. We screened 933 co-isogenic P-element insertion lines to identify candidate genes affecting starvation tolerance. A total of 383 P-element insertions induced highly significant and often sex-specific mutational variance in starvation resistance. We also used deficiency complementation mapping followed by complementation to mutations to identify 12 genes contributing to variation in starvation resistance between two wild-type strains. The genes we identified are involved in oogenesis, metabolism, and feeding behaviors, indicating a possible link to reproduction and survival. However, we also found genes with cell fate specification and cell proliferation phenotypes, which implies that resource allocation during development and at the cellular level may also influence the phenotypic response to starvation.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (59)
	Df(1)bi-DL1 Df(1)C149 Df(1)cho2 Df(1)dm75e19 Df(1)HC244 Df(1)JC19 Df(1)JC70 Df(1)N-8 Df(1)N-81k1 Df(1)rst2 Df(1)w258-45 Df(2L)b87e25 Df(2L)cact-255rv64 Df(2L)H20 Df(2L)J21 Df(2L)M36F-S6 Df(2L)N22-14 Df(2L)prd1.7 Df(2L)Prl Df(2L)r10 Df(2L)s1402 Df(2L)TE35BC-24 Df(2L)TW9 Df(2L)TW158 Df(2L)TW161 Df(2R)59AD Df(2R)AA21 Df(2R)B5 Df(2R)Chi^g230 Df(2R)cn9 Df(2R)Dll-MP Df(2R)ES1 Df(2R)eve Df(2R)exu1 Df(2R)H3C1 Df(2R)H3E1 Df(2R)min Df(2R)Np4 Df(2R)Np5 Df(2R)PI13 Df(2R)PK1 Df(2R)Pu-D17 Df(2R)Px1 Df(2R)Px2 Df(2R)ST1 Df(2R)stan1 Df(2R)stan2 Df(2R)w45-30n Df(2R)wun-GL Df(2R)X1 Df(2R)X3 Df(3L)BK10 Df(3L)Brd20 Df(3L)brm11 Df(3L)fz-D21 Df(3L)fz-GF3b Df(3L)fz-M21 T(2;3)Pu^Gr T(2;3)Pu^W
Alleles (109)
	Acon⁰⁷⁰⁵⁴ Acon^k07708 BG00080^BG00080 BG00158^BG00158 BG00372^BG00372 BG00378^BG00378 BG00459^BG00459 BG00488^BG00488 BG00489^BG00489 BG00829^BG00829 BG00977^BG00977 BG01020^BG01020 BG01046^BG01046 BG01047^BG01047 BG01095^BG01095 BG01128^BG01128 BG01130^BG01130 BG01228^BG01228 BG01257^BG01257 BG01296^BG01296 BG01353^BG01353 BG01367^BG01367 BG01428^BG01428 BG01485^BG01485 BG01515^BG01515 BG01526^BG01526 BG01564^BG01564 BG01572^BG01572 BG01575^BG01575 BG01613^BG01613 BG01656^BG01656 BG01664^BG01664 BG01740^BG01740 BG01799^BG01799 BG01856^BG01856 BG01862^BG01862 BG01891^BG01891 BG01950^BG01950 BG01954^BG01954 BG02058^BG02058 BG02063^BG02063 BG02100^BG02100 BG02131^BG02131 BG02201^BG02201 BG02257^BG02257 BG02330^BG02330 blw¹ blw^k00212 Bsg^BG02539 CG3638^BG00376 CG13377^BG01596 clt^BG01339 crol^k05205 dnc^81k1 dnc^M14 Egfr^k05115 emc^BG00986 Fhos^BG01659 JJF004^JJF004 JJF007^JJF007 JJF008^JJF008 JJF014^JJF014 JJF015^JJF015 JJF024^JJF024 JJF025^JJF025 JJF028^JJF028 JJF064^JJF064 JJF077^JJF077 JJF095^JJF095 JJF106^JJF106 JJF136^JJF136 JJF137^JJF137 JJF144^JJF144 JJF157^JJF157 JJF164^JJF164 JJF170^JJF170 JJF171^JJF171 JJF174^JJF174 JJF175^JJF175 JJF177^JJF177 JJF178^JJF178 JJF230^JJF230 JJF237^JJF237 l(2)03605⁰³⁶⁰⁵ l(2)07837⁰⁷⁸³⁷ l(2)k00611^k00611 l(2)k03205^k03205 l(2)k17002^k17002 l(2)rG270^rG270 l(2)ry50¹ mbl^BG01127 Mer^BG01543 numb¹ Pgi^nNC1 Pka-C1^DN Pka-C1^H2 pr¹ ptc^tuf-D Pu^AA1 Pu^Gr Pu^W px^A130.1F2 robo^BG01092 Rya-r44F^k04913 salm¹ sbb^BG01484 sd^BG02605 ssp2^BG01472 ttk^BG01491
Genes (125)
	Acon BG00080 BG00158 BG00372 BG00378 BG00459 BG00488 BG00489 BG00829 BG00977 BG01020 BG01046 BG01047 BG01095 BG01128 BG01130 BG01228 BG01257 BG01296 BG01353 BG01367 BG01428 BG01485 BG01515 BG01526 BG01564 BG01572 BG01575 BG01613 BG01656 BG01664 BG01740 BG01799 BG01856 BG01862 BG01891 BG01950 BG01954 BG02058 BG02063 BG02100 BG02131 BG02201 BG02257 BG02330 blw bou Bsg C1GalTA CG1678 CG3587 CG3638 CG5151 CG13377 CG15312 CG43736 Chd64 clt corto crol dnc Egfr emc fas Fhos fs(1)h fz JJF004 JJF007 JJF008 JJF014 JJF015 JJF024 JJF025 JJF028 JJF064 JJF077 JJF095 JJF106 JJF136 JJF137 JJF144 JJF157 JJF164 JJF170 JJF171 JJF174 JJF175 JJF177 JJF178 JJF230 JJF237 kek1 l(2)03605 l(2)07837 l(2)k00611 l(2)k03205 l(2)k17002 l(2)rG270 l(2)ry50 lcs mbl Mer NaCP60E numb Osi9 Pdk Pgi Pka-C1 pnt pr ptc Pu px Rab23 RapGAP1 robo Rya-r44F salm sbb sd shep ssp2 Tre1 ttk
Insertions (83)
	P{EP}dnc^EP1395 P{GawB}JJF004^JJF004 P{GawB}JJF007^JJF007 P{GawB}JJF008^JJF008 P{GawB}JJF014^JJF014 P{GawB}JJF015^JJF015 P{GawB}JJF024^JJF024 P{GawB}JJF025^JJF025 P{GawB}JJF028^JJF028 P{GawB}JJF064^JJF064 P{GawB}JJF077^JJF077 P{GawB}JJF095^JJF095 P{GawB}JJF106^JJF106 P{GawB}JJF136^JJF136 P{GawB}JJF137^JJF137 P{GawB}JJF144^JJF144 P{GawB}JJF157^JJF157 P{GawB}JJF164^JJF164 P{GawB}JJF170^JJF170 P{GawB}JJF171^JJF171 P{GawB}JJF174^JJF174 P{GawB}JJF175^JJF175 P{GawB}JJF177^JJF177 P{GawB}JJF178^JJF178 P{GawB}JJF230^JJF230 P{GawB}JJF237^JJF237 P{GT1}BG00080^BG00080 P{GT1}BG00158^BG00158 P{GT1}BG00372^BG00372 P{GT1}BG00378^BG00378 P{GT1}BG00459^BG00459 P{GT1}BG00488^BG00488 P{GT1}BG00489^BG00489 P{GT1}BG00829^BG00829 P{GT1}BG00977^BG00977 P{GT1}BG01020^BG01020 P{GT1}BG01046^BG01046 P{GT1}BG01047^BG01047 P{GT1}BG01095^BG01095 P{GT1}BG01128^BG01128 P{GT1}BG01130^BG01130 P{GT1}BG01228^BG01228 P{GT1}BG01257^BG01257 P{GT1}BG01296^BG01296 P{GT1}BG01353^BG01353 P{GT1}BG01367^BG01367 P{GT1}BG01428^BG01428 P{GT1}BG01485^BG01485 P{GT1}BG01515^BG01515 P{GT1}BG01526^BG01526 P{GT1}BG01564^BG01564 P{GT1}BG01572^BG01572 P{GT1}BG01575^BG01575 P{GT1}BG01613^BG01613 P{GT1}BG01656^BG01656 P{GT1}BG01664^BG01664 P{GT1}BG01740^BG01740 P{GT1}BG01799^BG01799 P{GT1}BG01856^BG01856 P{GT1}BG01862^BG01862 P{GT1}BG01891^BG01891 P{GT1}BG01950^BG01950 P{GT1}BG01954^BG01954 P{GT1}BG02058^BG02058 P{GT1}BG02063^BG02063 P{GT1}BG02100^BG02100 P{GT1}BG02131^BG02131 P{GT1}BG02201^BG02201 P{GT1}BG02257^BG02257 P{GT1}BG02330^BG02330 P{GT1}Bsg^BG02539 P{GT1}CG3638^BG00376 P{GT1}CG13377^BG01596 P{GT1}clt^BG01339 P{GT1}emc^BG00986 P{GT1}Fhos^BG01659 P{GT1}mbl^BG01127 P{GT1}Mer^BG01543 P{GT1}robo^BG01092 P{GT1}sbb^BG01484 P{GT1}sd^BG02605 P{GT1}ssp2^BG01472 P{GT1}ttk^BG01491