Reference Report

Reference
Citation	Rattner, B.P., Meller, V.H. (2004). Drosophila Male-Specific Lethal 2 Protein Controls Sex-Specific Expression of the roX Genes. Genetics 166(4): 1825--1832. (Export to RIS)
FlyBase ID	FBrf0174697
Publication Type	Research paper
PubMed ID	15126401
PubMed Abstract	The MSL complex of Drosophila upregulates transcription of the male X chromosome, equalizing male and female X-linked gene expression. Five male-specific lethal proteins and at least one of the two noncoding roX RNAs are essential for this process. The roX RNAs are required for the localization of MSL complexes to the X chromosome. Although the mechanisms directing targeting remain speculative, the ratio of MSL protein to roX RNA influences localization of the complex. We examine the transcriptional regulation of the roX genes and show that MSL2 controls male-specific roX expression in the absence of any other MSL protein. We propose that this mechanism maintains a stable MSL/roX ratio that is favorable for localization of the complex to the X chromosome.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (1)
	Df(1)52
Alleles (14)
	mle¹ mof¹ mof² msl-1^L60 msl-2¹ msl-2^Hsp83.PK msl-2^M63 msl-3² roX1^ex6 roX1^ex7B roX1^ex40A roX1^Hsp83.5' roX1^MB710 RpII215^+tcos4Δ4.3
Constructs (4)
	P{H83M2} P{Hsp83-5'-roX1} P{msl-2^M63} P{w⁺4Δ4.3}
Genes (8)
	mle mof msl-1 msl-2 msl-3 roX1 roX2 RpII215
Insertions (1)
	P{lArB}roX1^MB710