|Citation||Rattner, B.P., Meller, V.H. (2004). Drosophila Male-Specific Lethal 2 Protein Controls Sex-Specific Expression of the roX Genes. Genetics 166(4): 1825--1832. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||The MSL complex of Drosophila upregulates transcription of the male X chromosome, equalizing male and female X-linked gene expression. Five male-specific lethal proteins and at least one of the two noncoding roX RNAs are essential for this process. The roX RNAs are required for the localization of MSL complexes to the X chromosome. Although the mechanisms directing targeting remain speculative, the ratio of MSL protein to roX RNA influences localization of the complex. We examine the transcriptional regulation of the roX genes and show that MSL2 controls male-specific roX expression in the absence of any other MSL protein. We propose that this mechanism maintains a stable MSL/roX ratio that is favorable for localization of the complex to the X chromosome.|
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|Language of Publication||English|
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