Reference Report

Reference
Citation	Resino, J., Garcia-Bellido, A. (2004). Drosophila genetic variants that change cell size and rate of proliferation affect cell communication and hence patterning. Mech. Dev. 121(4): 351--364. (Export to RIS)
FlyBase ID	FBrf0174883
Publication Type	Research paper
PubMed ID	15110045
PubMed Abstract	We explore in this paper the role of genetic variants that affect cell size and proliferation in the determination of organ size. We use genetic mosaics of loss or gain of function in six different loci, which promotes smaller or larger than normal cells, associated to either smaller or larger than normal territories. These variants have autonomous effects on patterning and growth in mutant territories. However, there is no correlation between cell size or rate of proliferation on the size of the mutant territory. In addition, these mosaics show non-autonomous effects on surrounding wildtype cells, consisting always in a reduction in number of non-mutant cells. In all mutant conditions the final size (and shape) of the wing is different than normal. The phenotypes of the same variants include higher density of chaetae in the notum. These autonomous and non-autonomous effects suggest that the control of size in the wing is the result of local cell communication defining canonic distances between cells in a positional-values landscape.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (1)
	Df(3L)brm11
Alleles (11)
	ban^EP3622 cdc2^E1-24 ft⁴ gig¹⁰⁹ l(3)Me10¹ Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX} Scer\GAL4^ap-md544 Scer\GAL4^dpp.blk1 Scer\GAL4^en-e16E Scer\GAL4^tsh-md621
Constructs (3)
	P{Dp110^D954A} P{Dp110-CAAX} P{GAL4-dpp.blk1}
Genes (9)
	ban cdc2 ft gig l(3)Me10 Pi3K92E Scer\GAL4 T:Hsap\CAAX T:Hsap\MYC
Insertions (3)
	P{en2.4-GAL4}e16E P{GawB}ap^md544 P{GawB}tsh^md621