Reference Report

Reference
Citation	Isabel, G., Pascual, A., Preat, T. (2004). Exclusive consolidated memory phases in Drosophila. Science 304(5673): 1024--1027. (Export to RIS)
FlyBase ID	FBrf0175146
Publication Type	Research paper
PubMed ID	15143285
PubMed Abstract	Two types of consolidated memory have been described in Drosophila, anesthesia-resistant memory (ARM), a shorter-lived form, and stabilized long-term memory (LTM). Until now, it has been thought that ARM and LTM coexist. On the contrary, we show that LTM formation leads to the extinction of ARM. Flies devoid of mushroom body vertical lobes cannot form LTM, but spaced conditioning can still erase their ARM, resulting in a remarkable situation: The more these flies are trained, the less they remember. We propose that ARM acts as a gating mechanism that ensures that LTM is formed only after repetitive and spaced training.
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Secondary IDs	FBrf0179017
Language of Publication	English
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Publication Type	Journal
Abbreviation	Science
Title	Science
Publication Year	1895-
ISBN/ISSN	0036-8075
Data from Reference
Alleles (6)
	eas^unspecified rut²⁰⁸⁰ Scer\GAL4¹⁴⁷¹ Scer\GAL4^c739 Scer\GAL4^Mef2.247 shi^1.Scer\UAS
Constructs (2)
	P{Mef2-GAL4.247} P{UAS-shi^ts1.K}
Genes (7)
	amn dnc eas rad rut Scer\GAL4 shi
Insertions (2)
	P{GawB}1471 P{GawB}Hr39^c739